Immunohistochemical expression of AQP-3 in vitiligo: a new potential guide for disease activity
Immunohistochemical expression of AQP-3 in vitiligo: a new potential guide for disease activity
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DOI：
10.23736/s0392-0488.16.05248-2
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发表时间：
2017-08-01
影响因子：
2
通讯作者：
Mohamed, Shahdan
中科院分区：
文献类型：
--
作者：
Hodeib, Abeer;Hegab, Doaa;Mohamed, Shahdan
背景：白癜风是一种色素脱失性皮肤病，表皮黑素细胞功能消失。水通道蛋白-3（AQP-Y）是一种在表皮角质形成细胞中表达的水甘油通道蛋白，参与调节角质形成细胞的增殖和分化，可能间接影响黑素细胞。到目前为止，关于它在白癜风中可能的作用知之甚少。本研究旨在探讨AQP-3蛋白在白癜风组织中的表达变化，探讨其在白癜风发病机制中的作用。AQP-3在白癜风患者表皮中的表达为：+3为强表达，+12为中等表达，+1为弱表达，0为阴性表达。
BACKGROUND: Vitiligo is a depigmenting skin disorder, with disappearance of functioning epidermal melanocytes. Aquaporin-3 (AQP-Y) is an aquaglyceroporin expressed in epidermal keratinocytes, where it shares in regulating their proliferation and differentiation, and so it might affect melanocytes indirectly. So far, little is known regarding its possible role in vitiligo. This work aimed to study the changes in immunohistochemical expression of AQP-3 protein in vitiligo to detect its possible role in disease pathogenesis.METHODS: Skin biopsies were taken from lesional skin of 30 vitiligo patients in addition to 20 normal controls. Epidermal immunohistochemical expression of AQP-3 was assessed as: +3 = strong expression, +12 = moderate, +1= weak and 0= negative expression.RESULTS: AQP-3 was significantly less expressed in vitiligo epidermis than control (P