The structural brain correlates of neurological soft signs in ÆSOP first-episode psychoses study
The structural brain correlates of neurological soft signs in ÆSOP first-episode psychoses study
复制标题
DOI：
10.1093/brain/awh015
复制
发表时间：
2004-01-01
期刊：
影响因子：
14.5
通讯作者：
Murray, RM
中科院分区：
文献类型：
--
作者：
Dazzan, P;Morgan, KD;Murray, RM
精神分裂症和相关精神病患者有大量轻微的神经异常(神经软征)，其神经病理来源不明。这些问题包括运动协调性差、感官知觉困难和复杂运动任务排序困难。神经系统软征象似乎不能反映原发道或核病变。神经软体征是由特定的还是弥漫性的大脑结构异常引起的，这一点仍然有待确定。研究它们的解剖学相关性不仅可以更好地了解软体征的发病机制，而且可以更好地了解精神分裂症的病理生理学。令人惊讶的是，很少有研究研究神经软体征与大脑的相关性。在这项研究中，我们调查了77名首发精神病患者的流行病学样本中脑结构和神经软体征之间的关系。我们使用神经学评估量表进行神经学评估，并使用高分辨率磁共振成像和基于体素的图像分析方法来研究大脑结构。软性神经体征(运动和感觉)的发生率较高与皮质下结构(壳核、苍白球和丘脑)的灰质体积减少有关。感觉整合缺陷的迹象还与大脑皮层的体积减少有关，包括中央前回、上回、中回和舌回。神经软体征及其相关的脑变化与抗精神病药物的暴露无关。我们得出结论，神经软征与局部灰质体积的变化有关，它们可能代表皮层-皮质下连接受扰的临床迹象，推测这是精神障碍的基础。
Patients with schizophrenia and related psychoses have an excess of minor neurological abnormalities (neurological soft signs) of unclear neuropathological origin. These include poor motor coordination, sensory perceptual difficulties and difficulties in sequencing complex motor tasks. Neurological soft signs seem not to reflect primary tract or nuclear pathology. It still has to be established whether neurological soft signs result from specific or diffuse brain structural abnormalities. Studying their anatomical correlates can provide not only a better understanding of the aetiopathogenesis of soft signs, but also of the pathophysiology of schizophrenia. Surprisingly few studies have investigated the brain correlates of neurological soft signs. In the present study, we investigated the relationship between brain structure and neurological soft signs in an epidemiologically based sample of 77 first-episode psychosis patients. We used the Neurological Evaluation Scale for neurological assessment and high-resolution MRI and voxel-based methods of image analysis to investigate brain structure. Higher rates of soft neurological signs (both motor and sensory) were associated with a reduction of grey matter volume of subcortical structures (putamen, globus pallidus and thalamus). Signs of sensory integration deficits were additionally associated with volume reduction in the cerebral cortex, including the precentral, superior and middle temporal, and lingual gyri. Neurological soft signs and their associated brain changes were independent of antipsychotic exposure. We conclude that neurological soft signs are associated with regional grey matter volume changes and that they may represent a clinical sign of the perturbed cortical-subcortical connectivity that putatively underlies psychotic disorders.