"One Health" in tendinopathy research: Current concepts.
"One Health" in tendinopathy research: Current concepts.
复制标题
肌腱病研究中的“同一个健康”：当前概念。
DOI：
10.1002/jor.25035
复制
发表时间：
2021
期刊：
影响因子：
--
通讯作者：
Smith RKW
中科院分区：
文献类型：
--
作者：
Smith RKW
肌腱病仍然是影响人类和马运动员最常见的肌肉骨骼疾病之一，并提出了相当大的治疗挑战。下面的研讨会报告来自第三届Dorothy Havemeyer肌腱病研讨会，该研讨会提供了我们目前对诊断和治疗两种肌腱病的基础科学和临床挑战的理解的独特概述。病理上，肌腱表现出细胞、分子、结构和生物力学特征的改变，导致病理内型的谱。为了开发新的干预措施来管理、治疗或预防肌腱病变，了解导致肌腱衰竭、炎症再生和消退的潜在机制至关重要。马表现出与人类跟腱病（指浅屈肌腱）和鞘内肌腱套撕裂（指深屈肌腱撕裂）相似的病理，使医学和兽医领域的科学家和临床医生能够共同努力，匹配自然发生的疾病模型。人类医学在临床试验的设计、实施和影响方面的经验对马的临床试验有很多启示。有必要设计适当的研究来解决明确的问题，社会化研究以实现良好的入组，并考虑临床问题的重要性和影响以及解决它的成本。由于经济学通常是马医学的一个限制，因此应该仔细考虑使用观察性研究，特别是登记。
Tendinopathy remains one of the most common musculoskeletal disorders affecting both human and equine athletes and presents a considerable therapeutic challenge. The following workshop report comes from the third Dorothy Havemeyer Symposium of Tendinopathy which provided a unique overview of our current understanding of both the basic science and the clinical challenges for diagnosing and treating tendinopathy in both species. Pathologically, tendon demonstrates alterations in both cellular, molecular, structural, and biomechanical features, leading to a spectrum of pathological endotypes. To develop novel interventions to manage, treat or prevent tendinopathies it is vital to understand the underlying mechanisms that lead to both tendon failure, and also regeneration and resolution of inflammation. The horse shows analogous pathology with both human Achilles tendinopathy (superficial digital flexor tendon) and intrathecal rotator cuff tears (deep digital flexor tendon tears) enabling scientists and clinicians from both medical and veterinary fields to work jointly on matching naturally occurring disease models. The experience in human medicine on the design, conduct, and impact of clinical trials has much to inform clinical trials in horses. There is a need to design appropriate studies to address clear questions, socialize the study to achieve good enrollment, and consider the significance and impact of the clinical question as well as the cost of addressing it. Because economics is often a limitation in equine medicine the use of observational studies, and specifically registries, should be given careful consideration.