MR-detected changes in liver fat, abdominal fat, and vertebral bone marrow fat after a four-week calorie restriction in obese women
MR-detected changes in liver fat, abdominal fat, and vertebral bone marrow fat after a four-week calorie restriction in obese women
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DOI：
10.1002/jmri.24908
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发表时间：
2015-11-01
影响因子：
4.4
通讯作者：
Karampinos, Dimitrios C.
中科院分区：
文献类型：
--
作者：
Cordes, Christian;Dieckmeyer, Michael;Karampinos, Dimitrios C.
PurposeTo determine changes in bone marrow fat fraction（BMFF）in obesity after dietary intervention in comparison with changes in abdominal fat，liver fat，and serum lipids.Materials and MethodsTwenty obesity（BMI 34.923.8 kg/m2）women participated in a 4 week dietary intervention of 800 kcal/d plus additional vegetables.他们在干预前后进行了人体测量和血液价值测量。腹部3 T MRI测量皮下脂肪组织（SAT）和内脏脂肪组织（VAT）体积的变化，单体素磁共振波谱（MRS）测量肝脏和L5椎体的脂肪含量变化。（-40.3%），其次是VAT体积（-15.1%），血清脂质（-12.6至-14.5%）和SAT体积（-8.5%）。饮食干预后BMFF无统计学显著变化（P=0.39），但BMFF的绝对变化与SAT体积呈正相关（r=0.489），与非脂肪组织体积呈负相关（r=-0.493）。结论与SAT体积、VAT体积、肝脏脂肪和血脂4周的饮食干预后的肥胖和BMFF的变化取决于干预前的腹部组织体积。J. Magn. Reson. Imaging 2015;42：1272-1280.
PurposeTo determine changes in the bone marrow fat fraction (BMFF) in obesity after dietary intervention in comparison with changes in abdominal fat, liver fat, and serum lipids.Materials and MethodsTwenty obese (BMI 34.923.8 kg/m(2)) women participated in a 4-week dietary intervention of 800 kcal/d plus additional vegetables. They underwent anthropometric and blood value measurements before and after the intervention. Abdominal 3T MRI was performed to measure changes in subcutaneous adipose tissue (SAT) and visceral adipose tissue (VAT) volume and single-voxel magnetic resonance spectroscopy (MRS) to measure fat content changes in the liver and L5 vertebral body.ResultsThe greatest relative change after dietary intervention was found in the liver (-40.3%), followed by VAT volume (-15.1%), serum lipids (-12.6 to -14.5%), and SAT volume (-8.5%). There were no statistically significant changes in BMFF after dietary intervention (P=0.39), but absolute changes in the BMFF were positively associated with SAT volume (r=0.489) and negatively associated with nonadipose tissue volume (r=-0.493) before dietary intervention.ConclusionBone marrow behaves differently compared to SAT volume, VAT volume, liver fat, and serum lipids after a 4-week dietary intervention in obesity and BMFF changes depend on abdominal tissue volumes before intervention. J. Magn. Reson. Imaging 2015;42:1272-1280.