The neural basis of drug stimulus processing and craving: an activation likelihood estimation meta-analysis.
The neural basis of drug stimulus processing and craving: an activation likelihood estimation meta-analysis.
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DOI：
10.1016/j.biopsych.2011.05.025
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发表时间：
2011-10-15
影响因子：
10.6
通讯作者：
Hogarth L
中科院分区：
文献类型：
--
作者：
Chase HW;Eickhoff SB;Laird AR;Hogarth L
药物线索引发觅药行为的能力被认为在药物依赖中起着重要作用，但人类药物线索反应性的神经功能基础尚未完全了解。我们进行了一项荟萃分析，以确定大脑区域的药物线索的呈现一致激活。研究涉及寻求治疗和非寻求治疗的物质使用者进行了对比，以确定是否有一致的差异，这些人群之间的神经反应药物线索。最后，为了评估渴望的神经基础，评估了大脑区域中显示与渴望相关的激活的研究的一致性。通过PubMed数据库和文献检索获得了适当的研究，评估了药物相关线索或药物渴求在整个大脑中吸毒人群中的作用。激活似然估计是一种定量荟萃分析方法，通过对神经成像数据的空间不确定性进行建模来估计实验之间的收敛性，用于识别一致的激活区域。在腹侧纹状体（两个亚组）、杏仁核（治疗寻求亚组和总体）和眶额皮质（非治疗寻求亚组和总体）中观察到线索相关激活，但未观察到额叶皮质。虽然观察到亚组之间额叶和颞叶激活的不同模式，但这些差异并不显著。最后，右侧杏仁核和左侧额中回的活动与渴望呈正相关。这些结果证实了对药物线索和药物渴望的反应背后的关键神经基质。
The capacity of drug cues to elicit drug-seeking behavior is believed to play a fundamental role in drug dependence; yet the neurofunctional basis of human drug cue-reactivity is not fully understood. We performed a meta-analysis to identify brain regions that are consistently activated by presentation of drug cues. Studies involving treatment-seeking and nontreatment-seeking substance users were contrasted to determine whether there were consistent differences in the neural response to drug cues between these populations. Finally, to assess the neural basis of craving, consistency across studies in brain regions that show correlated activation with craving was assessed. Appropriate studies, assessing the effect of drug-related cues or manipulations of drug craving in drug-user populations across the whole brain, were obtained via the PubMed database and literature search. Activation likelihood estimation, a method of quantitative meta-analysis that estimates convergence across experiments by modeling the spatial uncertainty of neuroimaging data, was used to identify consistent regions of activation. Cue-related activation was observed in the ventral striatum (across both subgroups), amygdala (in the treatment-seeking subgroup and overall), and orbitofrontal cortex (in the nontreatment-seeking subgroup and overall) but not insula cortex. Although a different pattern of frontal and temporal lobe activation between the subgroups was observed, these differences were not significant. Finally, right amygdala and left middle frontal gyrus activity were positively associated with craving. These results substantiate the key neural substrates underlying reactivity to drug cues and drug craving.