Relative Pancreas Volume Is Reduced in First-Degree Relatives of Patients With Type 1 Diabetes
Relative Pancreas Volume Is Reduced in First-Degree Relatives of Patients With Type 1 Diabetes
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DOI：
10.2337/dc18-1512
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发表时间：
2019-02-01
期刊：
影响因子：
16.2
通讯作者：
Haller, Michael J.
中科院分区：
文献类型：
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作者：
Campbell-Thompson, Martha L.;Filipp, Stephanie L.;Haller, Michael J.
1型糖尿病患者和自身抗体（AAB）阳性的非糖尿病供体的胰腺大小减小。我们试图确定胰腺体积（PV）成像是否可以提高对1型糖尿病患者一级亲属（FDR）胰腺大小损失的理解。研究设计和方法我们进行了一项横断面研究，包括五组：AAB（-）对照组（无糖尿病且无1型糖尿病一级或二级亲属）（N = 49）、AAB（-）FDR（N = 61）、AAB（+）FDR（共N = 67例：n = 31例单一AAB阳性[AAB（+）单一]和n = 36例多重AAB阳性[AAB（+）多重]），以及近期发病的1型糖尿病患者（
OBJECTIVEPancreas size is reduced in patients at type 1 diabetes onset and in autoantibody (AAB)-positive donors without diabetes. We sought to determine whether pancreas volume (PV) imaging could improve understanding of the loss of pancreas size in first-degree relatives (FDRs) of patients with type 1 diabetes. We also examined relationships among PV, AAB status, and endocrine and exocrine functions.RESEARCH DESIGN AND METHODSWe conducted a cross-sectional study that included five groups: AAB(-) control subjects (no diabetes and no first- or second-degree relatives with type 1 diabetes) (N = 49), AAB(-) FDRs (N = 61), AAB(+) FDRs (N = 67 total: n = 31 with a single positive AAB [AAB(+) single] and n = 36 with multiple positive AABs [AAB(+) multiple]), and patients with recent-onset type 1 diabetes (