Normal values and clinical relevance of left atrial myocardial function analysed by speckle-tracking echocardiography: multicentre study
Normal values and clinical relevance of left atrial myocardial function analysed by speckle-tracking echocardiography: multicentre study
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DOI：
10.1093/ehjci/jeu219
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发表时间：
2015-04-01
影响因子：
6.2
通讯作者：
Boldt, Leif-Hendrik
中科院分区：
文献类型：
--
作者：
Morris, Daniel A.;Takeuchi, Masaaki;Boldt, Leif-Hendrik
目的-这个多中心研究的目的是确定正常范围和临床相关性的左心房（LA）的心肌功能分析二维斑点追踪超声心动图（2DSTE）。方法和结果我们分析了329例健康成人受试者前瞻性地包括在10个中心和验证组的377例左心室舒张功能障碍（LVDD）。采用左心房收缩期应变率峰值（LA-SRa）和舒张期应变率峰值（LA-Strain）分析左心房心肌功能。健康受试者的LA心肌功能值范围为LA-SRa -2.11 +/- 0.61 s（-1）和LA-应变45.5 +/-11.4%，这些LA分析的最低预期值（根据健康受试者的平均值计算为-1.96 SD）为LA-SRa -0.91 s（-1）和LA-应变23.1%。关于这些LA心肌分析的临床相关性，LA-SRa和LA-Strain检测到LVDD患者的轻微LA功能障碍，即使LA体积测量正常。此外，在这些患者中，我们发现，功能类（呼吸困难，NYHA分级）是负相关的LA应变和LA-SRa.Conclusion在目前的多中心研究分析了一个大的健康受试者和LVDD患者的队列，正常范围和临床相关性的LA使用2DSTE的心肌功能已被确定。
Aims The aim of this multicentre study was to determine the normal range and the clinical relevance of the myocardial function of the left atrium (LA) analysed by 2D speckle-tracking echocardiography (2DSTE).Methods and results We analysed 329 healthy adult subjects prospectively included in 10 centres and a validation group of 377 patients with left ventricular diastolic dysfunction (LVDD). LA myocardial function was analysed by LA strain rate peak during LA contraction (LA-SRa) and LA strain peak during LA relaxation (LA-Strain). The range of values of LA myocardial function in healthy subjects was LA-SRa -2.11 +/- 0.61 s(-1) and LA-Strain 45.5 +/- 11.4%, and the lowest expected values of these LA analyses (calculated as -1.96 SD from the mean of healthy subjects) were LA-SRa -0.91 s(-1) and LA-Strain 23.1%. Concerning the clinical relevance of these LA myocardial analyses, LA-SRa and LA-Strain detected subtle LA dysfunction in patients with LVDD, even though LA volumetric measurements were normal. In addition, in these patients we found that the functional class (dyspnoea-NYHA classification) was inversely related to both LA-Strain and LA-SRa.Conclusion In the present multicentre study analysing a large cohort of healthy subjects and patients with LVDD, the normal range and the clinical relevance of the myocardial function of the LA using 2DSTE have been determined.