XRCC1 Arg194Trp and Arg280His polymorphisms increase bladder cancer risk in Asian population: evidence from a meta-analysis.
XRCC1 Arg194Trp and Arg280His polymorphisms increase bladder cancer risk in Asian population: evidence from a meta-analysis.
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XRCC1 Arg194Trp 和 Arg280His 多态性增加亚洲人群患膀胱癌的风险：荟萃分析的证据
DOI：
10.1371/journal.pone.0064001
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Ye G
中科院分区：
文献类型：
--
作者：
Fang Z;Chen F;Wang X;Yi S;Chen W;Ye G
背景：已有大量研究探讨了X-射线交叉互补基因第1组(XRCC1)基因多态性与膀胱癌发病风险的关系，但在亚洲人群中的研究结果尚不明确。我们进行了Meta分析，以确定XRCC1 Arg194Trp、Arg280His和Arg399Gln基因多态与亚洲人群膀胱癌风险的关系。方法/主要发现关联强度用优势比(OR)和95%可信区间(95%CI)来衡量。共确定了9项合格研究，分别在中国、印度和日本进行。我们观察到显性模式(OR = 1.199，95%CI：1.021，1.408，P异质性 = 0.372)、Arg194Trp的等位基因比较(OR = 1.200，95%CI：1.057，1.362，P异质性 = 0.107)、杂合子比较(OR = 1.869，95%CI：1.205，2.898，P异质性 = 0.011)和显性模式(OR = 1.748，95%CI：1.054，2.900，P异质性 = )。根据调整后的OR估计的汇集结果进一步证实了这些发现。未检测到发表偏倚。分组分析发现，只有在基于社区的研究中才发现显著增加的风险，而不是基于医院的研究。没有证据表明存在发表偏见。结论XRCC1基因多态性与膀胱癌易感性的关系在亚洲尚属首次Meta分析。我们的Meta分析表明，XRCC1 Arg194Trp和Arg280His多态与亚洲人群膀胱癌风险显著增加相关。
Background A lot of studies have investigated the correlation between x-ray cross complementing group 1 (XRCC1) polymorphisms and bladder cancer risk, but the results in Asian population were still inconclusive. We conducted a meta-analysis to ascertain the association of XRCC1 Arg194Trp, Arg280His and Arg399Gln polymorphisms with bladder cancer risk in Asian population. Methodology/Principal findings The association strength was measured with odds ratios (ORs) and 95% confidence intervals (95% CIs). A total of 9 eligible studies, conducted in China, India and Japan, were identified. We observed a significant increased risk of bladder cancer in dominant model (OR = 1.199, 95% CI: 1.021,1.408, Pheterogeneity = 0.372), allele comparison (OR = 1.200, 95% CI: 1.057,1.362, Pheterogeneity = 0.107) of Arg194Trp, heterozygote comparison (OR = 1.869, 95% CI: 1.205,2.898, Pheterogeneity = 0.011) and dominant model (OR = 1.748, 95% CI: 1.054,2.900, Pheterogeneity = 0.01) of Arg280His. Pooled results estimated from adjusted ORs further validated these findings. No publication bias was detected. Subgroup analyses found that significant increased risk was only found among community-based studies not hospital-based studies. There was no evidence of publication bias. Conclusion This is the first meta-analysis conducted in Asian investigating the correlation between XRCC1 polymorphisms and susceptibility to bladder cancer. Our meta-analysis shows that XRCC1 Arg194Trp and Arg280His polymorphisms are associated with a significantly increased risk of bladder cancer in Asian population.
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影响因子：
8
作者：
Hao, B.;Miao, X.;He, F.
通讯作者：
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3.8
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