Effects of Allocating Livers for Transplantation Based on Model for End-Stage Liver Disease-Sodium Scores on Patient Outcomes
Effects of Allocating Livers for Transplantation Based on Model for End-Stage Liver Disease-Sodium Scores on Patient Outcomes
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DOI：
10.1053/j.gastro.2018.07.025
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发表时间：
2018-11-01
期刊：
影响因子：
29.4
通讯作者：
Moonka, Dilip
中科院分区：
文献类型：
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作者：
Nagai, Shunji;Chau, Lucy C.;Moonka, Dilip
背景与目的：终末期肝病和钠模型（MELD-Na）评分于2016年1月引入用于肝脏分配。我们评估了基于MELD-Na评分的肝脏分配对等待名单和移植后结局的影响。方法：我们检查了来自器官共享联合网络登记处的2个患者组; MELD期组由2013年6月18日至2016年1月10日登记为移植候选者的患者组成（n = 18，850），MELD-Na期组由2016年1月11日至2017年9月30日登记的患者组成（n = 14，512）。我们比较了等待名单和移植后的结果，并与血清钠浓度组之间的关联。结果：肝脏等候名单上90天内的死亡率下降（风险比[HR] 0.738，P
BACKGROUND & AIMS: The Model for End-stage Liver Disease and Sodium (MELD-Na) score was introduced for liver allocation in January 2016. We evaluated the effects of liver allocation, based on MELD-Na score, on waitlist and post-transplantation outcomes. METHODS: We examined 2 patient groups from the United Network for Organ Sharing registry; the MELD-period group was composed of patients who were registered as transplant candidates from June 18, 2013 through January 10, 2016 (n = 18,850) and the MELD-Na period group was composed of patients who were registered from January 11, 2016 through September 30, 2017 (n = 14,512). We compared waitlist and post-transplantation outcomes and association with serum sodium concentrations between groups. RESULTS: Mortality within 90 days on the liver waitlist decreased (hazard ratio [HR] 0.738, P