ABSOLUTE AND RELATIVE GROWTH OF RAT SKELETAL-MUSCLE
ABSOLUTE AND RELATIVE GROWTH OF RAT SKELETAL-MUSCLE
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DOI：
10.1016/0031-9384(94)00359-d
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发表时间：
1995-05-01
影响因子：
2.9
通讯作者：
UCHIYAMA, S
中科院分区：
文献类型：
--
作者：
TAMAKI, T;UCHIYAMA, S
在2 ~ 60周龄Wistar雄性大鼠中，测定了作为物理性质的体重和下肢长度的变化，作为整个肌肉性质的肌肉重量和长度的变化，以及作为肌内性质的纤维数、直径和增殖细胞数的变化。结果表明，肌肉重量（肌肉质量）的快速增长在出生后的“生长阶段”依赖于纵向和横向的增长。肌肉长度的增加是由于肌纤维的纵向生长，这可能是由于肌节数量的增加。肌围的增加取决于单个纤维直径（肌纤维肥大）和纤维数量（增生）的增加。“稳定期”（第10周后）肌肉质量的剩余增加完全是由横向生长引起的，主要取决于肌纤维肥大（但可能包括结缔组织的增加）。总之，为了研究运动和/或各种超负荷对肌肉肥大或增生的影响，特别是在Wistar大鼠的跖肌的情况下，它们应该是10-30周龄，体重超过300 g，因为在这个时期，它们的特征保持最恒定。
Change in body weight and lower hindlimb length as physical properties, muscle weight and length as whole-muscle properties, and fiber numbers, diameters, and numbers of proliferating cells as intramuscular properties, were measured in 2- to 60-week-old Wistar male rats. Results showed that the rapid increase in muscle weight (muscle mass) in the postnatal ''growing phase'' depended on the longitudinal and transverse growth. The increase in muscle length is due to longitudinal growth of muscle fiber, which may be derived from an increase in the number of sarcomeres. The increase in muscle girth depends on the increase of individual fiber diameter (muscle fiber hypertrophy) and fiber numbers (hyperplasia). The remaining increase in muscle mass in the ''steady phase'' (after the 10th week) is caused entirely by transverse growth, depending mainly on the muscle fiber hypertrophy (but may include increase of connective tissues). In conclusion, to study the effects of exercise and/or various overloads on muscle hypertrophy or hyperplasia, especially in the case of the plantaris muscle in Wistar rats, they should be 10-30 weeks old, and over 300 g in body weight, because in this period their characteristics remain most constant.