Diverse biological characteristics and varied virulence of H7N9 from Wave 5
Diverse biological characteristics and varied virulence of H7N9 from Wave 5
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第 5 波 H7N9 的多种生物学特性和不同的毒力。
DOI：
10.1080/22221751.2018.1560234
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发表时间：
2019-01-16
影响因子：
13.2
通讯作者：
Qin, Chuan
中科院分区：
文献类型：
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作者：
Bao, Linlin;Bi, Yuhai;Qin, Chuan
在第5波（2016-2017）期间，人类感染H7N9禽流感病毒（AIV）的人数大幅增加。为了研究H7N9是否变得更具感染性/传播性和致病性，我们用选自第5波的高致病性（HP）和低致病性（LP）-H7N9分离株表征了受体结合和实验感染的雪貂，并将其致病性和传播性与2013年的第1波分离株进行了比较。研究表明，A/Anhui/1/2013（LP）和A/Chicken/Heyuan/16876/2016（HP）对雪貂的毒力较高，A/Guangdong/Th 008/2017（HP）和A/Chicken/Huizhou/HZ-3/2017（HP）对雪貂的毒力中等，A/Shenzhen/Th 001/2016（LP）对雪貂的毒力较低。仅在感染A/Anhui/1/2013和A/Chicken/Heyuan/16876/2016的雪貂中观察到传播，这与患病雪貂将病毒传播给未感染动物的可能性较高的观点一致。鉴于在第5波传播的H7N9病毒中观察到的不同毒力和传播性，我们得出结论，与2013年相比，目前H7N9的公共卫生风险并未大幅增加，并且传播的病毒相当多样化。
There was a substantial increase with infections of H7N9 avian influenza virus (AIV) in humans during Wave 5 (2016-2017). To investigate whether H7N9 had become more infectious/transmissible and pathogenic overall, we characterized the receptor binding and experimentally infected ferrets with highly pathogenic (HP)- and low pathogenic (LP)-H7N9 isolates selected from Wave 5, and compared their pathogenicity and transmissibility with a Wave 1 isolate from 2013. Studies show that A/Anhui/1/2013 (LP) and A/Chicken/Heyuan/16876/2016 (HP) were highly virulent in ferrets, A/Guangdong/Th008/2017 (HP) and A/Chicken/Huizhou/HZ-3/2017 (HP) had moderate virulence and A/Shenzhen/Th001/2016 (LP) was of low virulence in ferrets. Transmission was observed only in ferrets infected with A/Anhui/1/2013 and A/Chicken/Heyuan/16876/2016, consistent with the idea that sicker ferrets had a higher probability to transmit virus to naive animals. Given the Varied virulence and transmissibility observed in circulating H7N9 viruses from Wave 5, we conclude that the current public health risk of H7N9 has not substantially increased compared to 2013 and the circulating viruses are quite diverse.