Na,K-ATPase Isozymes in Colorectal Cancer and Liver Metastases.
Na,K-ATPase Isozymes in Colorectal Cancer and Liver Metastases.
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DOI：
10.3389/fphys.2016.00009
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发表时间：
2016
影响因子：
4
通讯作者：
Martín-Vasallo P
中科院分区：
文献类型：
--
作者：
Baker Bechmann M;Rotoli D;Morales M;Maeso Mdel C;García Mdel P;Ávila J;Mobasheri A;Martín-Vasallo P
The goal of this study was to define Na,K-ATPase α and β subunit isoform expression and isozyme composition in colorectal cancer cells and liver metastases. The α1, α3, and β1 isoforms were the most highly expressed in tumor cells and metastases; in the plasma membrane of non-neoplastic cells and mainly in a cytoplasmic location in tumor cells. α1β1 and α3β1 isozymes found in tumor and metastatic cells exhibit the highest and lowest Na+ affinity respectively and the highest K+ affinity. Mesenchymal cell isozymes possess an intermediate Na+ affinity and a low K+ affinity. In cancer, these ions are likely to favor optimal conditions for the function of nuclear enzymes involved in mitosis, especially a high intra-nuclear K+ concentration. A major and striking finding of this study was that in liver, metastasized CRC cells express the α3β1 isozyme. Thus, the α3β1 isozyme could potentially serve as a novel exploratory biomarker of CRC metastatic cells in liver.
