Changing cancer incidence in Kampala, Uganda, 1991-2006
Changing cancer incidence in Kampala, Uganda, 1991-2006
复制标题
DOI：
10.1002/ijc.24838
复制
发表时间：
2010-03-01
影响因子：
6.4
通讯作者：
Wabinga, Henry R.
中科院分区：
文献类型：
--
作者：
Parkin, Donald Maxwell;Nambooze, Sarah;Wabinga, Henry R.
计算了Kyadondo县（乌干达坎帕拉）16年期间（1991-2006年）不同癌症的发病率。这一时期恰逢社会和生活方式不断变化，艾滋病毒/艾滋病流行达到高峰，随后又有所减弱。在这一时期，男女患癌症的风险总体上都有所增加，乳腺癌和前列腺癌的发病率尤其明显增加（每年4.5%）。前列腺癌是男性最常见的癌症。食道癌以前是男子最常见的癌症，妇女第二常见的癌症，其发病率保持相对稳定，而妇女最常见的恶性肿瘤-宫颈癌的发病率继续增加。自20世纪90年代初以来，男性卡波西肉瘤（KS）的发病率有所下降，而女性卡波西肉瘤的发病率相对稳定，但其诊断年龄越来越晚。儿童KS的发病率下降了约1/3。自1990年代中期以来，结膜鳞状细胞癌的发病率也有所下降。与撒哈拉以南非洲其他地区一样，乌干达的癌症控制涉及应对与生活方式西化有关的新癌症（大肠癌、乳腺癌和前列腺癌）的挑战;尽管与贫穷和感染有关的癌症（肝癌、宫颈癌、食道癌）的发病率几乎没有下降，但与艾滋病有关的癌症的残余负担仍然是一个重大负担。
Incidence rates of different cancers have been calculated for the population of Kyadondo County (Kampala, Uganda) for a 16-year period (1991-2006). This period coincides with continuing social and lifestyle changes and the peak and subsequent wane of the epidemic of HIV-AIDS. There has been an overall increase in the risk of cancer during the period in both sexes, with the incidence rates of cancers of the breast and prostate showing particularly marked increases (4.5% annually). Prostate cancer is now the most common cancer in men. The incidence of cancer of the esophagus, formerly the most common cancer in men and second in frequency in women, has remained relatively constant, whereas the incidence of cancer of the cervix, the most common malignancy in women, continues to increase. Since the early 1990s the incidence of Kaposi sarcoma (KS) in men has declined, and while remaining relatively constant in women, it has been diagnosed at progressively later ages. The rates of pediatric KS have declined by about 1/3rd. The incidence of squamous cell cancers of the conjunctiva has also declined since the mid 1990s. Cancer control in Uganda, as elsewhere in sub-Saharan Africa, involves meeting the challenge of emerging cancers associated with westernization of lifestyles (large bowel, breast and prostate); although the incidence of cancers associated with poverty and infection (liver, cervix, esophagus) shows little decline, the residual burden of the AIDS-associated cancers remains a major burden.