Preparation of manual movements in hemiparkinsonism.
Preparation of manual movements in hemiparkinsonism.
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偏侧帕金森症手动运动的准备。
DOI：
10.1136/jnnp.52.3.399
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发表时间：
1989
期刊：
影响因子：
--
通讯作者：
Lannon,MC
中科院分区：
文献类型：
--
作者：
Rafal,RD;Friedman,JH;Lannon,MC
在一项反应时间（RT）实验中，研究人员对20名患有不对称帕金森病的患者进行了研究，将受影响更严重（“坏”）的手与受影响较小（“好”）的手的表现进行了比较。简单RT和选择RT分块进行测试，简单RT条件下的提前信息（选择RT减去简单RT）所带来的益处作为运动准备的衡量标准。在简单RT和选择RT条件下，RT在“坏”手上的时间更长。事先得到的信息在两只手之间的效果没有差别。由此得出结论，帕金森病患者RT运动启动缓慢并非由于运动准备不足，并且该运动编程阶段不需要完整的基底神经节功能。
Twenty patients with asymmetric Parkinson's disease were studied in a reaction time (RT) experiment in which the performance of the more affected ("bad") hand was compared with performance of the less affected ("good") hand. Simple RT and choice RT were tested in separate blocks, and the benefit afforded by advance information in the simple RT condition (choice RT minus simple RT) served as a measure of motor preparation. RT was longer in the "bad" hand in both the simple RT and choice RT conditions. There was no difference in the effect of advance information between the two hands. It is concluded that slowness in RT movement initiation in Parkinson's disease is not due to a deficiency in motor preparation, and that intact basal ganglia function is not required for this stage of motor programming.