EFFERENT VAGAL INNERVATION OF CANINE VENTRICLE
EFFERENT VAGAL INNERVATION OF CANINE VENTRICLE
复制标题
DOI：
10.1152/ajpheart.1985.248.1.h89
复制
发表时间：
1985-01-01
影响因子：
--
通讯作者：
ZIPES, DP
中科院分区：
文献类型：
--
作者：
TAKAHASHI, N;BARBER, MJ;ZIPES, DP
研究了传出迷走神经纤维到达左心室的路径。在迷走神经刺激和持续输注去甲肾上腺素的过程中，在苯酚作用于心脏的选定部位阻断可能在该区域的迷走神经传出纤维之前和之后，测量左心室和间隔有效不应期（ERP）的变化。苯酚应用于右冠状动脉起始点与旋冠状动脉后降支之间的房室沟，可完全消除迷走神经诱导的左室前、后游离壁ERP的延长，减少但未消除室间隔ERP的延长。大的（3cm半径）心外膜苯酚能阻止所有犬迷走神经诱发的心外膜ERP延长，而小的（1cm半径）心外膜苯酚不能阻止任何犬迷走神经诱发的心外膜ERP改变。中间（2厘米半径）圈消除了18只狗中13只对ERP的迷走神经影响。苯酚的弧线复制了圆圈的上部，从顶点到底部依次涂抹，只有在靠近或在AV凹槽处涂抹时，才消除了传出迷走神经的影响。显然，大部分支配左室前、后心外膜的传出迷走神经纤维穿过心外膜表面0.25-0.5 mm（酚破坏深度）内的房室沟。在房室沟1-3厘米内，迷走神经传出纤维穿过左心室，沿壁内或心内膜下走行。
The route efferent vagal fibers travel to reach the left ventricle was investigated. Left ventricular and septal effective refractory period (ERP) changes were measured during vagal stimulation and a constant infusion of norepinephrine, before and after phenol was applied at selected sites of the heart to interrupt efferent vagal fibers that may be traveling in that area. Phenol applied to the atrioventricular (AV) groove between the origin of the right coronary artery anteriorly to the posterior descending branch of the circumflex coronary artery completely eliminated vagal-induced prolongation of ERP in the anterior and posterior left ventricular free wall and reduced, but did not eliminate, ERP prolongation in the septum. A large (3-cm radius) epicardial circle of phenol prevented vagal-induced ERP prolongation within the circle in all dogs, while a small (1-cm radius) epicardial circle of phenol fialed to prevent vagal-induced ERP changes within the circle in any dog. An intermediate (2-cm radius) circle eliminated vagal effects on ERP in 13 of 18 dogs. Arcs of phenol, to duplicate the upper portion of the circle, applied sequentially from apex to base eliminated efferent vagal effects only when painted near or at the AV groove. Apparently, the majority of efferent vagal fibers enroute to innervate the anterior and posterior left ventricular epicardium cross the AV groove within 0.25-0.5 mm (depth of phenol destruction) of the epicardial surface. Within 1-3 cm of the AV groove, vagal efferent fibers penetrate the left ventricle and travel an intramural or subendocardial course.