On the Continuity Between Autistic and Schizoid Personality Disorder Trait Burden: A Prospective Study in Adolescence.
On the Continuity Between Autistic and Schizoid Personality Disorder Trait Burden: A Prospective Study in Adolescence.
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关于自闭症和分裂样人格障碍特质负担之间的连续性：青春期的前瞻性研究。
DOI：
10.1097/nmd.0000000000001105
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发表时间：
2020
期刊：
影响因子：
--
通讯作者：
Constantino,JohnN
中科院分区：
文献类型：
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作者：
Cook,MichalLauren;Zhang,Yi;Constantino,JohnN
尽管高功能自闭症谱系障碍（ASD）和类分裂型人格障碍（分裂样PD）被广泛认为是不同的疾病，但它们具有相似的临床症状。本研究通过收集广泛验证的自闭症特征负担（社会反应量表，第二版）和分裂样PD影响（遗传研究诊断访谈）的测量方法，通过父母，老师和自我报告，从12至25岁的临床确定的有自闭症和无自闭症的言语男性（N= 72）中收集两种疾病之间的关系。虽然只有一小部分青少年ASD患者符合精神分裂样PD的全部诊断标准，但ASD患者认同精神分裂样PD特征的连续分布，与对照组相比，反映出明显的病理转变，有一半的ASD男性“经常”或“几乎总是”经历三个或更多的精神疾病诊断与统计手册，第四版精神分裂样PD标准项目。结果表明，青少年ASD患者的分裂样PD特征负担显著增加。对于有ASD发病前病史的精神分裂类PD患者，应考虑进行ASD特异性干预。
Although widely conceived as distinct conditions, higher-functioning autism spectrum disorder (ASD) and schizoid personality disorder (schizoid PD) share similar clinical symptomatology. This study explored the relationship between the two disorders by collecting extensively validated measures of autistic trait burden (Social Responsive Scale, Second Edition) and schizoid PD affectation (Diagnostic Interview for Genetic Studies) from clinically ascertained verbal males with and without autism ages 12 to 25 years (N= 72) via parent, teacher, and self-report. Although only a small minority of adolescents with ASD met full diagnostic criteria for schizoid PD, participants with ASD endorsed a continuous distribution of schizoid PD traits that reflected a pronounced pathological shift in comparison with those in the control group, with one half of ASD males experiencing three or more Diagnostic and Statistical Manual of Mental Disorders, 4th Edition schizoid PD criterion items “often” or “almost always.” Results suggest significant amplification of schizoid PD trait burden in adolescents with ASD. ASD-specific interventions should be considered for patients with schizoid PD with premorbid histories of ASD.