Epicardial fat: From the biomolecular aspects to the clinical practice
Epicardial fat: From the biomolecular aspects to the clinical practice
复制标题
DOI：
10.1016/j.biocel.2011.09.006
复制
发表时间：
2011-12-01
影响因子：
4
通讯作者：
Corsi, Massimiliano M.
中科院分区：
文献类型：
--
作者：
Iacobellis, Gianluca;Malavazos, Alexis E.;Corsi, Massimiliano M.
心外膜脂肪是心脏的内脏脂肪储藏库。它是一个代谢活跃的器官，在解剖和功能上与心肌相邻。心外膜脂肪被认为是一种二分作用。在生理条件下，心外膜脂肪表现出生化和生热心脏保护特性。在病理情况下，心外膜脂肪可通过血管分泌或旁分泌促炎细胞因子来局部影响心脏和冠状动脉。心外膜脂肪可以用成像技术测量。心外膜脂肪厚度反映腹内脂肪和心肌脂肪，并与代谢综合征和冠状动脉疾病相关。心外膜脂肪测量可能在心脏代谢风险分层中发挥作用，并作为治疗靶点。减肥和针对脂肪的抗炎药物可能会调节心外膜脂肪。由于心外膜和心肌组织共享相同的冠状动脉供应，因此可以合理地假设，改善局部血管形成可能使心外膜脂肪恢复其生理作用。(C)2011爱思唯尔有限公司。保留所有权利。
Epicardial fat is the visceral fat depot of heart. It is a metabolically active organ with anatomical and functional contiguity to the myocardium. A dichotomous role has been attributed to the epicardial fat. Under physiological conditions, epicardial fat displays biochemical and thermogenic cardio-protective properties. Under pathological circumstances epicardial fat can locally affect the heart and coronary arteries through vasocrine or paracrine secretion of pro-inflammatory cytokines. Epicardial fat can be measured with imaging techniques. Epicardial fat thickness reflects intra-abdominal and myocardial fat and correlates with metabolic syndrome and coronary artery disease. Epicardial fat measurement may play a role in the stratification of the cardio-metabolic risk and serve as therapeutic target. Weight loss and anti-inflammatory drugs targeting the fat may modulate epicardial fat. Because epicardial and myocardial tissues share the same coronary arterial supply it is reasonable to hypothesize that improved local vascularisation may resume epicardial fat to its physiological role. (C) 2011 Elsevier Ltd. All rights reserved.