Familial transmission of mood disorders: Convergence and divergence with transmission of suicidal behavior
Familial transmission of mood disorders: Convergence and divergence with transmission of suicidal behavior
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DOI：
10.1097/01.chi.0000135619.38392.78
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发表时间：
2004-10-01
影响因子：
13.3
通讯作者：
Mann, JJ
中科院分区：
文献类型：
--
作者：
Brent, DA;Oquendo, M;Mann, JJ
目的：心境障碍和自杀行为都是家族性的。在这项研究中，作者检查了与这两种相关疾病的家族性传播相关的因素，以了解哪些是共同的或独特的家族性传播危险因素。方法：对141例心境障碍先证者的285名子女进行研究。通过单变量统计、Logistic和Cox回归以及通径分析，对与子女情绪障碍相关的先证者和子女特征进行了检验。结果：父母的性虐待史与子女情绪障碍的风险增加有关。父母性虐待和子女情绪障碍之间的关系通过子女冲动攻击、性虐待和焦虑症进行调节。在后代中，较高水平的冲动攻击性与较早出现情绪障碍的年龄有关。子代自杀企图主要与子代情绪障碍有关，此外还有子代性虐待和冲动攻击性行为。结论：情绪障碍和自杀未遂的家族传播途径相似，但不完全相同。通过针对高危家庭预防早发性情绪障碍可能有助于防止自杀行为的传播。因为这些数据是横断面的，所以这些结果必须通过前瞻性的随访来证实。
Objective: Both mood disorder and suicidal behavior are familial. In this study, the authors examine the factors associated with the familial transmission of these two related conditions to learn which are shared or unique risk factors for familial transmission. Method: The 285 offspring of 141 probands with mood disorder were studied. Proband and offspring characteristics associated with offspring mood disorder were examined by univariate statistics, logistic and Cox regression, and path analysis. Results: Parental history of sexual abuse was associated with an increased risk of offspring mood disorder. The relationship between parent sexual abuse and offspring mood disorder was mediated by offspring impulsive aggression, sexual abuse, and anxiety disorder. In offspring, higher levels of impulsive aggression were associated with earlier age at onset of mood disorder. Offspring suicide attempt was mainly related to offspring mood disorder, with additional contributions from offspring sexual abuse and impulsive aggression. Conclusions: The pathways associated with the familial transmission of mood disorder and of suicide attempt are similar but not identical. Prevention of early-onset mood disorder by targeting high-risk families may help to prevent the transmission of suicidal behavior. Because these data are cross-sectional, these results must be confirmed by prospective follow-up.