Positive association between soil arsenic concentration and mortality from alzheimer's disease in mainland China
Positive association between soil arsenic concentration and mortality from alzheimer's disease in mainland China
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中国大陆土壤砷浓度与阿尔茨海默病死亡率呈正相关
DOI：
10.1016/j.jtemb.2020.126452
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发表时间：
2020-05-01
影响因子：
3.5
通讯作者：
Shen, Xiao-Li
中科院分区：
文献类型：
--
作者：
Li, Xue-Lian;Zhan, Run-Qing;Shen, Xiao-Li
目的：本研究旨在探讨中国大陆土壤砷（As）浓度与阿尔茨海默病（AD）死亡率之间的关系。研究设计：生态学研究。方法：本研究纳入中国大陆22个省份和3个市辖区。 1990年土壤中砷浓度从中国国家环境保护局获得； 1991年至2000年AD年死亡率数据来自中国国家死因监测数据库。利用这些数据，我们计算了土壤 As 浓度与 AD 死亡率之间的 Spearman 相关系数，以及按四分位数划分研究组的土壤 As 水平与 AD 死亡率之间的相对风险 (RR)。 结果：A 土壤 As 浓度与 AD 死亡率之间的 Spearman 相关系数分别为 0.552 (p = 0.004)、0.616 (p = 0.001) 和 0.622 (p = 0.001)。分别为（残积层）、C 土壤 As（母质层）和总土壤 As（A 土壤 As + C 土壤 As）。当A土As浓度超过9.05 mg/kg、10.40 mg/kg和13.10 mg/kg时，相对风险分别为0.835（95% CI：0.832、0.838）、1.969（95% CI：1.955、1.982）、2.939（95% CI： 2.920、2.958）；当C土As达到9.45 mg/kg、11.10 mg/kg和13.55 mg/kg时，相对风险分别为4.349（95% CI：4.303、4.396）、6.108（95% CI：6.044、6.172）和9.125（95% CI：9.033， 9.219），分别。土壤中的铅、镉和汞浓度与 AD 死亡率之间没有发现相关性。结论：AD 死亡率存在明显的土壤砷浓度依赖性增加。这项研究的结果可能为砷暴露与 AD 死亡风险之间可能存在因果关系提供证据。
Objectives: The current study was designed to investigate the relationship between the soil arsenic (As) concentration and the mortality from Alzheimer's disease (AD) in mainland China.Study design: Ecological study.Methods: Twenty-two provinces and 3 municipal districts in mainland China were included in this study. The As concentrations in soil in 1990 was obtained from the China State Environmental Protection Bureau; the data on annual mortality of AD from 1991 to 2000 were obtained from the National Death Cause Surveillance Database of China. Using these data, we calculated the spearman correlation coefficient between soil As concentration and AD mortality, and the relative risk (RR) between soil As levels and AD mortality by quartile-dividing study groups.Results: The spearman correlation coefficient between As concentration and AD mortality was 0.552 (p = 0.004), 0.616 (p = 0.001) and 0.622 (p = 0.001) in the A soil As (eluvial horizon), the C soil As (parent material horizon), and the Total soil As (A soil As + C soil As), respectively. When the A soil As concentration was over 9.05 mg/kg, 10.40 mg/kg and 13.10 mg/kg, the relative risk was 0.835 (95 % CI: 0.832, 0.838), 1.969 (95 %CI: 1.955, 1.982), and 2.939 (95 % CI: 2.920, 2.958), respectively; when the C soil As reached 9.45 mg/kg, 11.10 mg/kg and 13.55 mg/kg, the relative risk was 4.349 (95 % CI: 4.303, 4.396), 6.108 (95 % CI: 6.044, 6.172), and 9.125 (95 %CI: 9.033, 9.219), respectively. No correlation was found between lead, cadmium, and mercury concentration in the soil and AD mortality.Conclusion: There was an apparent soil As concentration dependent increase in AD mortality. Results of this study may provide evidence for a possible causal linkage between arsenic exposure and the death risk from AD.