Endothelial function in conduit and resistance arteries in men with coronary disease
Endothelial function in conduit and resistance arteries in men with coronary disease
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DOI：
10.1016/j.atherosclerosis.2005.03.025
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发表时间：
2006-01-01
期刊：
影响因子：
5.3
通讯作者：
Kublickiene, K
中科院分区：
文献类型：
--
作者：
Agewall, S;Henareh, L;Kublickiene, K
本研究的目的是确定导管动脉内皮功能的无创测量是否反映了体外测量的皮下阻力动脉的内皮功能，并检查既往心肌梗死患者的阻力动脉中是否也存在内皮功能障碍。在 25 名既往患有心肌梗塞的患者和 8 名年龄相匹配的健康受试者中，测量了肱动脉直径对充血血流刺激的反应，并使用体外方法（压力肌动描记法）直接评估从皮下脂肪活检获得的动脉中血流介导的反应。与冠状动脉疾病组相比，健康组中血流介导的肱动脉扩张更为明显，分别为 5.1 +/- 2.5% 和 2.6 +/- 2.1% (p < 0.05)。与对照受试者相比，CHD 患者皮下动脉中血流介导的扩张显着减少（例如，最大流速为 204 μl/min 时初始收缩前的百分比变化：42 +/- 7% CHD (n = 25) 对比 84 +/- 24% 对照 (it = 8)，ANOVA，p = 0.03）。肱动脉的血流介导的扩张与微血管水平的最大血流介导的扩张之间存在显着相关性（p < 0.01）。 总之，本研究表明，与年龄匹配的健康对照组相比，心肌梗死后患者的导管和阻力循环中的内皮功能障碍。此外，观察到大导管动脉和阻力动脉中通过血流介导的扩张的内皮功能之间存在显着且独立的关系。 (c) 2005 Elsevier Ireland Ltd. 保留所有权利。
The aims of this study were to determine whether non-invasive measurement of endothelial function in conduit arteries reflects that of subcutaneous resistance arteries measured in vitro and to examine whether there is an endothelial dysfunction also in resistance arteries in patients with a previous myocardial infarction. The brachial artery diameter responses to a hyperemic flow stimulus and an in vitro method, pressure myography, to directly evaluate flow-mediated responses in arteries obtained from biopsies of subcutaneous fat were measured in 25 patients with a previous myocardial infarction and in 8 aged matched healthy subjects. Flow-mediated dilatation of the brachial artery was more pronounced in the healthy group compared with the group with coronary disease, 5.1 +/- 2.5% and 2.6 +/- 2.1%, respectively (p < 0.05). The flow-mediated dilatation in subcutaneous arteries from CHD patients was significantly reduced compared to control subjects (e.g. percent change from initial preconstriction at maximum flow rate of 204 mu l/min: 42 +/- 7% CHD (n = 25) versus 84 +/- 24% control (it = 8), ANOVA, p = 0.03). There was a significant correlation between flow-mediated dilatation of the brachial artery and maximum flow-mediated dilatation at microvascular level, (p < 0.01).In conclusion this study demonstrates endothelial dysfunction in both conduit and resistance circulation in patients after myocardial infarction compared to an aged-matched healthy control group. Furthermore, a significant and independent relationship between endothelial function by means of flow-mediated dilatation in large conduit arteries and resistance arteries was observed. (c) 2005 Elsevier Ireland Ltd. All rights reserved.