Self-referential reflective activity and its relationship with rest: a PET study
Self-referential reflective activity and its relationship with rest: a PET study
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DOI：
10.1016/j.neuroimage.2004.11.048
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发表时间：
2005-04-01
期刊：
影响因子：
5.7
通讯作者：
Salmon, E
中科院分区：
文献类型：
--
作者：
D'Argembeau, A;Collette, F;Salmon, E
本研究利用正电子发射断层扫描（PET）来确定自我参照反思活动的大脑基质，并探究其与静息状态下活跃的大脑区域的关系。13名健康志愿者在接受扫描时执行与三种不同事项（自我、他人和社会问题）相关的反思任务。还获取了静息扫描数据，在此过程中，受试者被要求只是放松，不要进行系统性思考。每次扫描期间所经历的心理活动都通过评定量表进行评估。结果显示，尽管在自我参照任务期间自我参照思维最为频繁，但在静息期间也会出现一些自我参照反思活动。与静息状态相比，执行反思任务与背内侧前额叶皮质、左侧颞中回前部、双侧颞极以及右侧小脑的血流增加有关；右侧前额叶区域以及内侧和右侧顶叶区域的血流减少。此外，腹内侧前额叶皮质（VMPFC）（1）在自我参照反思任务期间比在其他两种反思任务期间更活跃，（2）在静息和自我参照任务期间显示出共同的激活，以及（3）显示出大脑新陈代谢与自我参照加工量之间存在相关性。这表明VMPFC对于表征与自我相关的知识至关重要，并且这是静息状态的一项重要功能。（c）2004爱思唯尔公司。保留所有权利。
This study used positron emission tomography (PET) to identify the brain substrate of self-referential reflective activity and to investigate its relationship with brain areas that are active during the resting state. Thirteen healthy volunteers performed reflective tasks pertaining to three different matters (the self, another person, and social issues) while they were scanned. Rest scans were also acquired, in which subjects were asked to simply relax and not think in a systematic way. The mental activity experienced during each scan was assessed with rating scales. The results showed that, although self-referential thoughts were most frequent during the self-referential task, some self-referential reflective activity also occurred during rest. Compared to rest, performing the reflective tasks was associated with increased blood flow in the dorsomedial prefrontal cortex, the left anterior middle temporal gyros, the temporal pole bilaterally, and the right cerebellum; there was a decrease of blood flow in right prefrontal regions,and in medial and right lateral parietal regions. In addition, the ventromedial prefrontal cortex (VMPFC) (1) was more active during the self-referential reflective task than during the other two reflective tasks, (2) showed common activation during rest and the self-referential task, and (3) showed a correlation between cerebral metabolism and the amount of self-referential processing. It is suggested that the VMPFC is crucial for representing knowledge pertaining to the self and that this is an important function of the resting state. (c) 2004 Elsevier Inc. All rights reserved.