Separating lexical-semantic access from other mnemonic processes in picture-name verification.
Separating lexical-semantic access from other mnemonic processes in picture-name verification.
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DOI：
10.3389/fpsyg.2013.00706
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发表时间：
2013
影响因子：
3.8
通讯作者：
Horwitz B
中科院分区：
文献类型：
--
作者：
Smith JF;Braun AR;Alexander GE;Chen K;Horwitz B
我们提出了一种新的范式，以确定共享和独特的大脑区域的基础非语义，非语音，抽象，视听（AV）的记忆与命名使用纵向功能磁共振成像实验。参与者接受培训，以关联新的AV刺激对包含隐藏的语言内容。一半的刺激对是动物的扭曲图像和动物名字的正弦波语音版本。图像和声音被扭曲，使其语言内容只有在意识到其存在后才容易识别。通过呈现AV对并要求参与者验证两个刺激是否形成了学习配对来测试配对的记忆。在记忆测试后，隐藏的语言内容被揭示出来，参与者再次接受测试，以回忆他们在这种语言知情状态下的配对。一旦通知，AV验证任务可以通过命名图片来执行。在识别非语言感觉记忆和命名的区域之间有大量的重叠，表明它们之间有很强的联系。会议之间的对比确定左角回和颞中回的关键额外的球员在命名网络。左下额叶区域参与命名和非语言AV记忆，这表明该地区是负责AV记忆独立的语音内容，与以前的建议。当执行命名的AV任务时，角回与左额下回和左颞中回之间的功能连接增加。结果是一致的假设，即在fMRI的空间分辨率，促进非语言AV协会的区域是一个子集，促进命名，虽然重组成不同的网络。
We present a novel paradigm to identify shared and unique brain regions underlying non-semantic, non-phonological, abstract, audio-visual (AV) memory vs. naming using a longitudinal functional magnetic resonance imaging experiment. Participants were trained to associate novel AV stimulus pairs containing hidden linguistic content. Half of the stimulus pairs were distorted images of animals and sine-wave speech versions of the animal's name. Images and sounds were distorted in such a way as to make their linguistic content easily recognizable only after being made aware of its existence. Memory for the pairings was tested by presenting an AV pair and asking participants to verify if the two stimuli formed a learned pairing. After memory testing, the hidden linguistic content was revealed and participants were tested again on their recollection of the pairings in this linguistically informed state. Once informed, the AV verification task could be performed by naming the picture. There was substantial overlap between the regions involved in recognition of non-linguistic sensory memory and naming, suggesting a strong relation between them. Contrasts between sessions identified left angular gyrus and middle temporal gyrus as key additional players in the naming network. Left inferior frontal regions participated in both naming and non-linguistic AV memory suggesting the region is responsible for AV memory independent of phonological content contrary to previous proposals. Functional connectivity between angular gyrus and left inferior frontal gyrus and left middle temporal gyrus increased when performing the AV task as naming. The results are consistent with the hypothesis that, at the spatial resolution of fMRI, the regions that facilitate non-linguistic AV associations are a subset of those that facilitate naming though reorganized into distinct networks.