Epigenetic regulation of the expression of genes involved in steroid hormone biosynthesis and action.
Epigenetic regulation of the expression of genes involved in steroid hormone biosynthesis and action.
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DOI：
10.1016/j.steroids.2010.02.004
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发表时间：
2010-07
期刊：
影响因子：
2.7
通讯作者：
Papadopoulos, Vassilios
中科院分区：
文献类型：
--
作者：
Martinez-Arguelles, Daniel B.;Papadopoulos, Vassilios
关键词：
类固醇激素参与器官发育、生殖、体内平衡和应激反应。类固醇机制以发育和组织特异性的方式表达，这些因子的表达受到一系列转录因子（tf）的严格调节。表观遗传学通过DNA甲基化和组蛋白尾部修饰提供了额外的基因调控层。关键的类固醇酶的表观遗传调控的证据正在增加，尽管这似乎不是一个主要的调控途径。类固醇激素通过属于NR3A和NR3C家族的类固醇核受体在靶组织中发挥作用。核受体表达水平和翻译后修饰调节其功能并决定其对类固醇配体的敏感性。核受体和tf比参与类固醇生成的蛋白质更可能受到表观遗传调控，并且对这些类固醇生成酶的表达具有次要影响。在这里，我们回顾了与类固醇生物发生和作用相关的酶、转录因子和核受体的表观遗传调控的证据。
Steroid hormones participate in organ development, reproduction, body homeostasis, and stress responses. The steroid machinery is expressed in a development- and tissue-specific manner, with the expression of these factors being tightly regulated by an array of transcription factors (TFs). Epigenetics provides an additional layer of gene regulation through DNA methylation and histone tail modifications. Evidence of epigenetic regulation of key steroidogenic enzymes is increasing, though this does not seem to be a predominant regulatory pathway. Steroid hormones exert their action in target tissues through steroid nuclear receptors belonging to the NR3A and NR3C families. Nuclear receptor expression levels and post-translational modifications regulate their function and dictate their sensitivity to steroid ligands. Nuclear receptors and TFs are more likely to be epigenetically regulated than proteins involved in steroidogenesis and have secondary impact on the expression of these steroidogenic enzymes. Here we review evidence for epigenetic regulation of enzymes, transcription factors, and nuclear receptors related to steroid biogenesis and action.
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DOI：
10.1083/jcb.200409107
发表时间：
2004-12-06
期刊：
The Journal of cell biology
影响因子：
--
作者：
Davidoff MS;Middendorff R;Enikolopov G;Riethmacher D;Holstein AF;Müller D
通讯作者：
Müller D
影响因子：
--
作者：
Flück, CE;Miller, WL
通讯作者：
Miller, WL
影响因子：
4.1
作者：
Brinkmann, AO
通讯作者：
Brinkmann, AO
影响因子：
4.1
作者：
Ge, RS;Dong, Q;Hardy, MP
通讯作者：
Hardy, MP
影响因子：
3.8
作者：
Armenti, AnnMarie E.;Zama, Aparna Mahakah;Passantino, Lisa;Uzumcu, Mehmet
通讯作者：
Uzumcu, Mehmet