THE ROLE OF VERTEBRAL AND INTERNAL CAROTID-ARTERY DISEASE IN THE PATHOGENESIS OF VERTEBROBASILAR TRANSIENT ISCHEMIC ATTACKS
THE ROLE OF VERTEBRAL AND INTERNAL CAROTID-ARTERY DISEASE IN THE PATHOGENESIS OF VERTEBROBASILAR TRANSIENT ISCHEMIC ATTACKS
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DOI：
10.1007/bf02189960
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发表时间：
1993-03-01
影响因子：
4.7
通讯作者：
FAUSTMANN, P
中科院分区：
文献类型：
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作者：
DELCKER, A;DIENER, HC;FAUSTMANN, P
彩色多普勒超声改善了椎动脉（VA）血流动力学的评价。VA的正常血管、发育不全、狭窄和闭塞之间的可靠区分现在可以做出。我们在一项前瞻性研究中对两组患者进行了研究，分别为单纯颈动脉疾病（n = 48）和颈动脉和椎动脉疾病（n = 14），以确定VA在椎基底动脉系统短暂性脑缺血发作（TIA）发病机制中的作用。除了现有的颈内动脉的动脉病变外，VA的状况对椎基底动脉区域TIA的发生也很重要。我们发现，8%的患者孤立的血流动力学相关狭窄或闭塞的一个或两个颈内动脉有短暂性脑缺血发作的椎基底动脉领域。合并颈动脉和椎动脉疾病的患者在同一区域的TIA增加了71%。这一组中TIA的高发生率可能归因于颈动脉和椎动脉疾病的联合作用，因为第三组（n = 30）孤立性椎动脉疾病仅显示13%的TIA。
Color-coded duplex sonography has improved the evaluation of the hemodynamics of the vertebral arteries (VA). A reliable differentiation between a normal vessel, hypoplasia, stenosis and occlusion of VA can now be made. We studied two groups of patients in a prospective study with isolated carotid artery disease (n = 48), and with a combination of carotid and vertebral artery disease (n = 14), to determine the role of VA in the pathogenesis of transient ischemic attacks (TIAs) in the vertebrobasilar system. Apart from the existing arteriosclerotic changes of the internal carotid arteries, the condition of the VA was of importance for the occurrence of TIAs in the vertebrobasilar territory. We found that 8% of the patients with isolated hemodynamically relevant stenosis or occlusion of one or both internal carotid arteries had a TIA in the vertebrobasilar territory. Patients with combined carotid and vertebral artery disease had an increase of TIAs in the same region in 71%. The high rate of TIAs in this group might be attributed to the combined effect of carotid and vertebral artery disease, as a third group (n = 30) with isolated vertebral artery disease showed TIAs in only 13%.