Biofilm Disrupting Technology for Orthopedic Implants: What's on the Horizon?
Biofilm Disrupting Technology for Orthopedic Implants: What's on the Horizon?
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DOI：
10.3389/fmed.2014.00022
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发表时间：
2014
影响因子：
3.9
通讯作者：
Sabesan VJ
中科院分区：
文献类型：
--
作者：
Connaughton A;Childs A;Dylewski S;Sabesan VJ
骨科植入物在关节中的使用彻底改变了许多慢性肌肉骨骼疾病（如骨关节炎）患者的治疗。然而，将异物引入人体会使身体易于感染。这些感染的治疗已经变得非常复杂，因为骨科植入物作为多种细菌的表面，一次生长成耐生物膜层。这种生物膜层作为植入物上细菌菌落的保护剂，使它们在使用标准抗生素治疗时更具抗性且难以根除。在某些情况下，单独使用抗生素甚至使细菌对治疗更具抗药性。因此，非抗生素抗生物膜剂的产生激增，以帮助破坏骨科植入物上的生物膜，从而帮助消除感染。在这项研究中，我们讨论了肩部骨科植入物的感染，然后我们回顾了已用于治疗骨科植入物感染的抗生物膜剂的主要类别。然后，我们介绍了一些在过去几年中研究的更新的生物膜破坏技术，这些技术可能会在未来推进骨科植入物的治疗选择。
The use of orthopedic implants in joints has revolutionized the treatment of patients with many debilitating chronic musculoskeletal diseases such as osteoarthritis. However, the introduction of foreign material into the human body predisposes the body to infection. The treatment of these infections has become very complicated since the orthopedic implants serve as a surface for multiple species of bacteria to grow at a time into a resistant biofilm layer. This biofilm layer serves as a protectant for the bacterial colonies on the implant making them more resistant and difficult to eradicate when using standard antibiotic treatment. In some cases, the use of antibiotics alone has even made the bacteria more resistant to treatment. Thus, there has been surge in the creation of non-antibiotic anti-biofilm agents to help disrupt the biofilms on the orthopedic implants to help eliminate the infections. In this study, we discuss infections of orthopedic implants in the shoulder then we review the main categories of anti-biofilm agents that have been used for the treatment of infections on orthopedic implants. Then, we introduce some of the newer biofilm disrupting technology that has been studied in the past few years that may advance the treatment options for orthopedic implants in the future.