Breast Arterial Calcification Is Not Associated with Mild Cognitive Impairment or Incident All-Cause Dementia Among Postmenopausal Women: The MINERVA Study.
Breast Arterial Calcification Is Not Associated with Mild Cognitive Impairment or Incident All-Cause Dementia Among Postmenopausal Women: The MINERVA Study.
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乳腺动脉钙化与绝经后妇女的轻度认知障碍或全因痴呆无关：MINERVA 研究。
DOI：
10.1089/jwh.2020.8372
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发表时间：
2021
期刊：
影响因子：
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通讯作者：
Yaffe,Kristine
中科院分区：
文献类型：
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作者：
Iribarren,Carlos;Chandra,Malini;Molloi,Sabee;Sanchez,Gabriela;Azamian-Bidgoli,Fatemeh;Cho,Hyo-Min;Ding,Huanjun;Yaffe,Kristine
背景：由于血管危险因素与认知能力下降有关，而乳腺动脉钙化 (BAC) 与血管风险相关，因此我们推测 BAC 可能与认知障碍和痴呆有关。 方法：我们使用了 3,913 名 60-79 岁无症状女性的多种族队列，这些妇女是在 2012-2015 年大型健康计划中进行乳房 X 光检查后招募的。 BAC 质量分数 (mg) 来自数字乳房 X 光检查。使用蒙特利尔认知评估 (MoCA) 在基线处测量认知功能，并使用经过验证的 ICD-9 和 ICD-10 代码确定全因痴呆事件（n= 49 例；中位随访 = 5.6 年）。我们使用 BAC 的 MoCA 评分的横断面线性回归，然后使用多项 Logistic 回归预测轻度认知障碍不会进展为痴呆和事件性全因痴呆，最后使用事件性全因痴呆的 Cox 回归。 结果：在未调整或调整的分析中，未发现 MoCA 评分与 BAC 存在之间存在线性回归关联。与没有 BAC 的女性相比，患有严重（上三分位）BAC 的女性的 MoCA 评分低 0.58 分（标准误差 [SE] = 0.18）。但经过多变量调整后，这种差异消失了。在未调整或调整分析中，多项 Logistic 回归中未发现 BAC 存在或分级存在显着关联。未发现 BAC 存在与全因痴呆事件之间存在显着关联（完全调整的风险比 = 0.74；95% 置信区间：0.39–1.39）。同样，BAC 分级与全因痴呆事件没有显着关联。结论：我们的结果不支持 BAC 的存在或分级可能导致认知障碍或全因痴呆发展的假设。
Background:Since vascular risk factors are implicated in cognitive decline, and breast arterial calcification (BAC) is related to vascular risk, we postulated that BAC may be associated with cognitive impairment and dementia.Methods:We used a multiethnic cohort of 3,913 asymptomatic women 60–79 years of age recruited after mammography screening at a large health plan in 2012–2015. A BAC mass score (mg) was derived from digital mammograms. Cognitive function was measured at baseline using the Montreal Cognitive Assessment (MoCA) and incident all-cause dementia (n= 49 events; median follow-up = 5.6 years) were ascertained with validated ICD-9 and ICD-10 codes. We used cross-sectional linear regression of MoCA scores on BAC, then multinomial logistic regression predicting mild cognitive impairment not progressing to dementia and incident all-cause dementia and, finally, Cox regression of incident all-cause dementia.Results:No association by linear regression was found between MoCA scores and BAC presence in unadjusted or adjusted analysis. Women with severe (upper tertile) BAC had a MoCA score lower by 0.58 points (standard error [SE] = 0.18) relative to women with no BAC. However, this difference disappeared after multivariate adjustment. No significant associations were found in multinomial logistic regression for either BAC presence or gradation in unadjusted or adjusted analysis. No significant associations were found between BAC presence with incident all-cause dementia (fully adjusted hazard ratio = 0.74; 95% confidence interval: 0.39–1.39). Likewise, no significant association with incident all-cause dementia was noted for BAC gradation.Conclusions:Our results do not support the hypothesis that BAC presence or gradation may contribute to cognitive impairment or development of all-cause dementia.