Differential effects of acute ethanol treatment on cardiac contractile function in young adult and senescent mice.
Differential effects of acute ethanol treatment on cardiac contractile function in young adult and senescent mice.
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急性乙醇治疗对年轻成年和衰老小鼠心脏收缩功能的不同影响。
DOI：
10.1016/s0741-8329(01)00154-9
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发表时间：
2001
期刊：
影响因子：
--
通讯作者：
Watson,RR
中科院分区：
文献类型：
--
作者：
Shi,J;Larson,DF;Yang,B;Hunter,K;Gorman,M;Montes,S;Beischel,J;Watson,RR
据了解，与衰老相关的心血管组织发生显著的生化、分子和性能改变。因此，在比较年轻人和老年人时，心血管对乙醇消耗的反应可能存在差异，这是合乎逻辑的。我们比较了6、15月龄（衰老）小鼠和16月龄（衰老）诱导型一氧化氮合酶敲除小鼠（n=7）在60%乙醇（2 g/kg, i.p）急性治疗前后的左心室功能。将米勒1.4 Fr电导/微压计导管置入小鼠左心室，获取压力-容量环路。与年轻小鼠相比，衰老组的心脏收缩功能明显下降。乙醇处理后，年轻小鼠的心脏功能显著下降，心脏指数下降28%，收缩末期弹性下降29%，负荷前可恢复的中风功下降16% （P< 0.01）。相反，衰老小鼠的收缩功能显著增加，收缩末期弹性增加40% (P< 0.01)，预负荷可恢复的中风功增加19% （P< 0.05）。老年组心肌环鸟苷一磷酸水平显著升高（P< 0.001），经乙醇处理后降低68.5% （P< 0.001）。Northern blot分析显示，诱导型一氧化氮合酶信息仅在衰老心肌组织中存在。此外，衰老诱导型一氧化氮合酶敲除小鼠的心功能与年轻小鼠相当，乙醇处理后心功能明显下降，与年轻小鼠相同，心脏指数下降26% (P< 0.05)，负荷前可再生卒中功下降23% （P< 0.01）。由此可见，老年小鼠的心血管功能差异和对急性乙醇给药的反应与诱导型一氧化氮合酶活性有关。
It is understood that marked biochemical, molecular, and performance alterations occur in cardiovascular tissues related to aging. It is logical, therefore, that differences in the cardiovascular response to ethanol consumption, when comparing younger with older individuals, may exist. We compared the left ventricular function of 6- and 15-month-old (senescent) mice and 16-month-old (senescent) inducible nitric oxide synthase knockout mice (n=7 each) before and subsequent to acute treatment with 60% ethanol (2 g/kg, i.p.). A Millar 1.4 Fr conductance/micromanometer catheter was placed into the left ventricle of the mice for acquisition of pressure–volume loops. Heart contractile functions were significantly decreased in the senescent group, compared with findings in the younger mice. Subsequent to ethanol treatment, the younger mice showed a significant reduction in cardiac function, with a 28% decrease in cardiac index, a 29% decrease in end-systolic elastance, and a 16% decrease in preload recruitable stroke work (P<.01). Conversely, the senescent mice showed significantly increased contractile function, with a 40% increase in end-systolic elastance (P<.01) and a 19% increase in preload recruitable stroke work (P<.05). The myocardial cyclic guanosine monophosphate levels were significantly higher in the older group (P<.002), and subsequent to ethanol treatment, they were decreased by 68.5% (P<.001). Northern blot analysis demonstrated inducible nitric oxide synthase message only in senescent myocardial tissues. Moreover, the cardiac function of senescent inducible nitric oxide synthase knockout mice was comparable with that of young mice, and after ethanol treatment, cardiac function decreased significantly, just as that for young mice did, with a 26% decrease in cardiac index (P<.05) and a 23% decrease in preload recruitable stroke work (P<.01). It was concluded that the differential cardiovascular function and response to acute ethanol administration was related to the inducible nitric oxide synthase activity present only in senescent mice.
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影响因子：
9.8
作者：
Kay, HH;Grindle, KM;Magness, RR
通讯作者：
Magness, RR
影响因子：
5
作者：
Q. Chen;F. LaBella
通讯作者：
F. LaBella
正常和脓毒症心脏中心肌细胞的旁分泌调节。
影响因子：
3.7
作者：
S. Corda;A. Mebazaa;B. Tavernier;M. Ayed;D. Payen
通讯作者：
D. Payen
影响因子：
5
作者：
Stein, B;Frank, P;Thoenes, M
通讯作者：
Thoenes, M
DOI：
10.1111/j.1530-0277.1995.tb01521.x
发表时间：
1995-04-01
影响因子：
3.2
作者：
GREENBERG, S;XIE, JM;MASON, C
通讯作者：
MASON, C