Aggregation of Nano- and Micro-Crystallites in Urine of Uric Acid Stone Formers and Healthy Controls
Aggregation of Nano- and Micro-Crystallites in Urine of Uric Acid Stone Formers and Healthy Controls
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DOI：
10.4028/www.scientific.net/amr.1052.279
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发表时间：
2014-10
期刊：
影响因子：
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通讯作者：
Cai-Yan Tan;Qiong-Zhi Gan;Jun-fa Xue;Ouyang Ming Jian
中科院分区：
文献类型：
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作者：
Cai-Yan Tan;Qiong-Zhi Gan;Jun-fa Xue;Ouyang Ming Jian
采用纳米颗粒分析仪对5例尿酸结石患者和5例健康对照者尿液中不同大小尿微粒的聚集情况进行了比较研究。分别用孔径为0.22、0.45、1.2、3、8 μm的微孔滤膜过滤尿液，得到不同大小的尿液微晶。在致石患者中，平均粒径（）随放置时间（t）迅速增加。对照组的尿微晶值随时间的延长而缓慢增加。随着t值的增加，两种尿微粒的自相关曲线变得不光滑，相关曲线的衰减变慢，结石患者和对照组不同大小的尿微粒的衰减时间均增加。这些结果表明，正常人尿中的晶体比患者的更稳定。尿酸结石患者尿中微晶的快速聚集可能是影响微晶生长的重要因素。
The aggregation of urine crystallites with different sizes in the urines of 5 cases of uric acid (UA) calculi patients and 5 cases of healthy controls were comparatively investigated by means of nanoparticle size analyzer. Different sizes of urine crystallites were obtained by filtrating the urine through microporous membrane with different pore sizes (0.22, 0.45, 1.2, 3, and 8 μm), respectively. The average particle size () increased rapidly with placement time (t) in the lithogenic patients. The values of the urine crystallites of the controls increased more slowly with t. When t was increased, the autocorrelation curves in the two types of urine crystallites became less smooth and the decay of the correlation curve became slower, and decay time of different sizes of urine crystallites both for the calculi patients and the controls increased. These results indicated that the urine crystallites of the controls were more stable than those of the patients. The rapid aggregation of urine crystallites may be an important factor affecting the growth of crystallites in UA stone patients.