Citrus auraptene acts as an agonist for PPARs and enhances adiponectin production and MCP-1 reduction in 3T3-L1 adipocytes
Citrus auraptene acts as an agonist for PPARs and enhances adiponectin production and MCP-1 reduction in 3T3-L1 adipocytes
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DOI：
10.1016/j.bbrc.2007.11.119
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发表时间：
2008-02-01
影响因子：
3.1
通讯作者：
Kawada, Teruo
中科院分区：
文献类型：
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作者：
Kuroyanagi, Kayo;Kang, Min-Sook;Kawada, Teruo
柑橘类水果化合物具有许多促进健康的作用。在这项研究中，使用荧光素酶配体测定系统，我们表明，柑橘橙内酯激活过氧化物酶体增殖物激活受体（PPAR）-α和PPAR γ。金萝卜素诱导脂联素表达上调，并增加脂联素高分子量多聚体的数量占总脂联素的比例。与此相反，在3 T3-L1脂肪细胞中，金萝卜素抑制单核细胞趋化蛋白（MCP）-1的表达。使用PPARgamma拮抗剂的实验表明，这些对脂联素和MCP-1表达的调节作用是由PPARgamma激活引起的。结果表明，桔红素激活脂肪细胞中的PPAR γ，以控制脂肪细胞因子如脂联素和MCP-1，并表明食用含有桔红素的柑橘类水果可以部分预防脂质和葡萄糖代谢异常。(c)2007年爱思唯尔公司All rights reserved.
Citrus fruit compounds have many health-enhancing effects. In this study, using a luciferase ligand assay system, we showed that citrus auraptene activates peroxisome proliferator-activated receptor (PPAR)-alpha and PPAR gamma. Auraptene induced up-regulation of adiponectin expression and increased the ratio of the amount of high-molecular-weight multimers of adiponectin to the total adiponectin. In contrast, auraptene suppressed monocyte chemoattractant protein (MCP)-1 expression in 3T3-L1 adipocytes. Experiments using PPAR gamma antagonist demonstrated that these effects on regulation of adiponectin and MCP-1 expression were caused by PPAR gamma activations. The results indicate that auraptene activates PPAR gamma in adipocytes to control adipocytekines such as adiponectin and MCP-1 and suggest that the consumption of citrus fruits, which contain auraptene can lead to a partial prevention of lipid and glucose metabolism abnormalities. (c) 2007 Elsevier Inc. All rights reserved.