Sex differences in metabolic homeostasis, diabetes, and obesity.
Sex differences in metabolic homeostasis, diabetes, and obesity.
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DOI：
10.1186/s13293-015-0033-y
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发表时间：
2015
影响因子：
7.9
通讯作者：
Mauvais-Jarvis F
中科院分区：
文献类型：
--
作者：
Mauvais-Jarvis F
在男性和女性中，代谢稳态控制的基本方面是不同的。这种性别不对称代表了女性抵抗能量储存损失的进化范式。这一观点讨论了最根本的性别差异在代谢稳态，糖尿病和肥胖。遗传性别的作用、男性产前睾酮的编程作用以及青春期性激素的激活作用共同产生了男性和女性两种不同的生物系统，需要分别研究。这些能量稳态和代谢功能障碍的性别特异性差异代表了一个未经测试的因素来源，可以利用这些因素来开发糖尿病，代谢综合征和肥胖症的相关性别治疗途径。
There are fundamental aspects of the control of metabolic homeostasis that are regulated differently in males and females. This sex asymmetry represents an evolutionary paradigm for females to resist the loss of energy stores. This perspective discusses the most fundamental sex differences in metabolic homeostasis, diabetes, and obesity. Together, the role of genetic sex, the programming effect of testosterone in the prenatal period in males, and the activational role of sex hormones at puberty produce two different biological systems in males and females that need to be studied separately. These sex-specific differences in energy homeostasis and metabolic dysfunction represent an untested source of factors that can be harnessed to develop relevant sex-based therapeutic avenues for diabetes, metabolic syndrome, and obesity.