Repair of Strand Breaks by Homologous Recombination
Repair of Strand Breaks by Homologous Recombination
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DOI：
10.1101/cshperspect.a012740
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发表时间：
2013-11-01
影响因子：
7.2
通讯作者：
Rothstein, Rodney
中科院分区：
文献类型：
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作者：
Jasin, Maria;Rothstein, Rodney
在这篇综述中，我们讨论了使用同源DNA序列（即，同源重组[HR]），主要集中在酵母和哺乳动物。我们提供了一个历史的背景下，目前的看法，人力资源和描述如何DSB处理在人力资源以及与其他DSB修复途径的相互作用。我们讨论了酶学的过程中，其次是研究DSB修复活细胞。只要有可能，我们引用原始文章和评论，以帮助读者进一步研究。
In this review, we discuss the repair of DNA double-strand breaks (DSBs) using a homologous DNA sequence (i.e., homologous recombination [HR]), focusing mainly on yeast and mammals. We provide a historical context for the current view of HR and describe how DSBs are processed during HR as well as interactions with other DSB repair pathways. We discuss the enzymology of the process, followed by studies on DSB repair in living cells. Whenever possible, we cite both original articles and reviews to aid the reader for further studies.