Reply to a letter to the editor regarding "Short stature is associated with low flow-mediated vasodilation in Japanese men"
Reply to a letter to the editor regarding "Short stature is associated with low flow-mediated vasodilation in Japanese men"
复制标题
回复关于“日本男性身材矮小与低流量介导的血管舒张有关”的编辑信
DOI：
10.1038/s41440-022-00919-y
复制
发表时间：
2022
期刊：
影响因子：
5.4
通讯作者：
Harada T
中科院分区：
文献类型：
--
作者：
Higashi Y;Kajikawa M;Harada T
我们感谢 Murakami 博士和 Shiraishi 博士对我们的文章感兴趣，该文章展示了通过血流介导的血管舒张评估的身高与内皮功能之间的关系 [1]。尽管即使在调整了血流介导的血管舒张的各种混杂因素之后，与 < 155.0 cm 组相比，较高身高组与 FMD 低四分位数风险降低显着相关，但身高与血流介导的血管舒张之间的反比关系的潜在机制以及身高与血流介导的血管舒张之间的联系仍不清楚。如前所述，我们之前表明增强指数和血流介导的血管舒张之间存在反比关系[2]。不幸的是，在本研究中，我们没有关于增强指数的数据。从推导增强指数的本构方程和目前的结果来看，我们同意他们关于我们研究中身高和增强指数之间存在负相关的推测。毫无疑问，身高、增强指数和血流介导的血管舒张之间存在着密切的关联，无论增强指数和血流介导的血管舒张之间关系的原因或结果如何。我们将在未来的研究中尝试确认身高和增强指数之间的关系。此外，由于使用多种无创中心血压测量方法，未来的研究需要为增强指数建立明确的参考值，以及心血管风险增加的明确截止值。身高在心血管疾病和心血管事件临界值中的作用也应该得到证实。
We thank Dr. Murakami and Dr. Shiraishi for their interest in our article showing an association of body height with endothelial function assessed by flow-mediated vasodilation [1]. Although the greater-height groups were significantly associated with a decreased risk of a low quartile of FMD compared with the< 155.0 cm group even after adjustment for various confounders for flow-mediated vasodilation, the mechanism underlying the inverse relationship between body height and flow-mediated vasodilation and the connection between body height and flow-mediated vasodilation remain unclear. As noted, we previously showed an inverse relationship between the augmentation index and flow-mediated vasodilation [2]. Unfortunately, in the present study, we did not have data on the augmentation index. From the constitutive equation for deriving the augmentation index and the present results, we agree with their speculation on an inverse correlation between body height and the augmentation index in our study. There seems to be no doubt that there is a close association among height, augmentation index, and flow-mediated vasodilation, regardless of the cause or consequence of the relationship between the augmentation index and flow-mediated vasodilation. We will attempt to confirm the relationship between body height and augmentation index in a future study. In addition, future studies are needed to establish a clear reference value for the augmentation index due to the use of multiple noninvasive central blood pressure measurement methods and a clear cutoff value for increased cardiovascular risk. The role of body height in the cutoff value for cardiovascular disease and cardiovascular events should also be confirmed.