Muscle activity and kinematics show different responses to recurrent laryngeal nerve lesion in mammal swallowing
Muscle activity and kinematics show different responses to recurrent laryngeal nerve lesion in mammal swallowing
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DOI：
10.1152/jn.00409.2020
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发表时间：
2020-12-01
影响因子：
2.5
通讯作者：
German, Rebecca Z.
中科院分区：
文献类型：
--
作者：
Gould, Francois D. H.;Lammers, Andrew R.;German, Rebecca Z.
Gould FD, Lammers AR, Mayerl C, Ohlemacher J, German RZ。哺乳动物吞咽时喉返神经损伤对肌肉活动和运动学的影响不同。[J] .中国生物医学工程学报，2016,31(4):557 - 557。首次发布于2020年9月23日；doi: 10.1152 / jn.00409.2020。-了解神经系统和肌肉骨骼系统之间的相互作用是识别功能衰竭机制的关键。哺乳动物的吞咽是一个复杂的运动过程。喉返神经是上呼吸道的一种感觉和运动神经，其损伤可导致吞咽过程中气道保护失效（液体进入气道），机制尚不清楚。我们研究了8头仔猪喉返神经损伤后肌肉和运动变化与气道保护的关系。我们测试了两个假设：1)运动和肌肉功能在有气道保护失效和没有气道保护失效的燕子损伤后都会发生变化；2)运动和肌肉功能的差异将预测气道保护失效是否发生在病变和完整的猪身上。我们用高速视频透视和同时肌电图记录吞咽的口咽肌前和喉返神经病变后。病变改变了气道保护与舌骨和舌骨运动时间的关系。病变后喉肌的发作和持续时间的变化与气道保护结果的相关性较小。舌骨和舌骨的运动学都能预测病变前后不同的气道保护结果。只有一块舌骨下肌和一块舌骨上肌的活动开始和持续时间在病变前后表现出预测关系的变化。与肌肉激活模式相比，舌骨和舌骨的运动学更直接地反映病变前后气道保护的变化。识别气道保护失效的机制需要特定的功能假设，将神经运动输出与肌肉激活和特定运动联系起来。吞咽中使用的口咽结构的运动学和肌肉活动模式显示出对喉返神经病变的不同反应模式。了解肌肉如何作用于结构产生行为是理解神经控制的必要条件。
Gould FD, Lammers AR, Mayerl C, Ohlemacher J, German RZ. Muscle activity and kinematics show different responses to recur-rent laryngeal nerve lesion in mammal swallowing. J Neurophysiol 124: 1743-1753, 2020. First published September 23, 2020; doi:10.1152/ jn.00409.2020.-Understanding the interactions between neural and musculoskeletal systems is key to identifying mechanisms of func-tional failure. Mammalian swallowing is a complex, poorly under-stood motor process. Lesion of the recurrent laryngeal nerve, a sensory and motor nerve of the upper airway, results in airway protection failure (liquid entry into the airway) during swallowing through an unknown mechanism. We examined how muscle and kinematic changes after recurrent laryngeal nerve lesion relate to airway protection in eight infant pigs. We tested two hypotheses: 1) kinematics and muscle function will both change in response to lesion in swallows with and without airway protection failure, and 2) differences in both kinematics and muscle function will predict whether airway protection failure occurs in lesion and intact pigs. We recorded swallowing with high-speed videofluoroscopy and si-multaneous electromyography of oropharyngeal muscles pre-and postrecurrent laryngeal nerve lesion. Lesion changed the relation-ship between airway protection and timing of tongue and hyoid movements. Changes in onset and duration of hyolaryngeal muscles postlesion were less associated with airway protection outcomes. The tongue and hyoid kinematics all predicted airway protection out-comes differently pre-and postlesion. Onset and duration of activity in only one infrahyoid and one suprahyoid muscle showed a change in predictive relationship pre-and postlesion. Kinematics of the tongue and hyoid more directly reflect changes in airway protections pre-and postlesion than muscle activation patterns. Identifying mech-anisms of airway protection failure requires specific functional hypotheses that link neural motor outputs to muscle activation to spe-cific movements.NEW & NOTEWORTHY Kinematic and muscle activity pat-terns of oropharyngeal structures used in swallowing show dif-ferent patterns of response to lesion of the recurrent laryngeal nerve. Understanding how muscles act on structures to produce behavior is necessary to understand neural control.