Sodium MR imaging of acute and subacute stroke for assessment of tissue viability
Sodium MR imaging of acute and subacute stroke for assessment of tissue viability
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DOI：
10.1016/j.nic.2005.08.003
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发表时间：
2005-08-01
影响因子：
2.3
通讯作者：
Kassam, A
中科院分区：
文献类型：
--
作者：
Thulborn, KR;Davis, D;Kassam, A
3.0 T的钠磁共振成像在可接受的采集时间内提供高质量的图像，允许通过维持钠离子稳态来评估组织活力。这一应用是可行的临床中风评估有效的投影脉冲序列与极短的回声时间值。这种扭曲投影成像在3.0 t下，在不到10分钟的时间内提供足够分辨率的高信噪比图像（5 X 5 X 5 mm(3)）。图像被量化为组织钠浓度（TSC）图，可以直接根据组织活力进行解释。对于梗死，基线TSC值低于45 mmol/L以可变速率增加到约70 mmol/L，从而可以监测卒中病理生理学的进展。
Sodium MR imaging at 3.0 T provides high-quality images in acceptable acquisition times that allow assessment of tissue viability as defined by maintenance of sodium ion homeostasis. This application is made feasible for clinical stroke evaluation by an efficient projection pulse sequence with extremely short echo time values. This twisted projection imaging provides high signal-to-noise images at adequate resolution (5 X 5 X 5 mm(3)) in less than 10 minutes at 3.0 T. The images are quantified as tissue sodium concentration (TSC) maps that can be interpreted directly in terms of tissue viability. With infarction, baseline TSC values of less than 45 mmol/L increase at variable rates to approximately 70 mmol/L, allowing monitoring of the progression of stroke pathophysiology.