Decreased entorhinal cortex volumes in schizophrenia
Decreased entorhinal cortex volumes in schizophrenia
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DOI：
10.1016/j.schres.2007.11.035
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发表时间：
2008-07-01
影响因子：
4.5
通讯作者：
Brambilla, Paolo
中科院分区：
文献类型：
--
作者：
Baiano, Monica;Perlini, Cinzia;Brambilla, Paolo
背景：内嗅皮层位于内侧颞叶，参与记忆和学习。之前的 MRI 研究报告了精神分裂症的相互矛盾的发现，显示内嗅大小正常或缩小。目的：探讨从南维罗纳地理界定的集水区（即 100,000 名居民）招募的大量精神分裂症患者样本的内嗅皮层体积。我们还研究了作为内侧颞叶一部分的海马体的大小。方法：70 名精神分裂症患者和 77 名正常对照者接受了 MRI 扫描（TR = 2060 ms，TE = 3.9 ins，切片厚度 = 1.25 mm）。使用 Brains2 软件探索内嗅和海马体积。结果：发现总内嗅皮层存在显着的群体效应，但海马没有，与正常受试者相比，精神分裂症患者的内嗅体积较小（F = 6.24，p = 0.01），特别是在战斗一侧（F = 9.76，p = 0.002）。此外，正常人的内嗅皮质偏侧性指数高于精神分裂症患者（F=5.45，p=0.02）。结论：与之前的一些报告一致，我们的研究证实，大量精神分裂症患者存在内嗅体积异常减少的情况，特别是右侧，并且还发现了不对称性的改变。这可能在该疾病的精神病理学和认知障碍中发挥重要作用。未来的纵向 MRI 研究（包括高危受试者和未用药的首发患者）对于进一步了解内嗅皮层萎缩是否在疾病发作时就已经存在或作为疾病的结果而出现至关重要。 (c) 2007 Elsevier B.V. 保留所有权利。
Background: The entorhinal cortex is located in the medial temporal lobe and is involved in memory and learning. Previous MRI studies reported conflicting findings in schizophrenia, showing normal or reduced entorhinal size. Objectives: To explore entorhinal cortex volumes in a large sample of patients with schizophrenia recruited from the geographically defined catchment area of South Verona (i.e. 100,000 inhabitants). We also investigated the size of hippocampus as part of the medial temporal lobe.Methods: 70 patients with schizophrenia and 77 normal controls underwent a session of MRI (TR=2060 ms, TE=3.9 ins, slice thickness=1.25 mm). Entorhinal and hippocampal volumes were explored using the Brains2 software.Results: A significant group effect was found for total entorhinal cortex but not for hippocampus, with patients suffering from schizophrenia having smaller entorhinal volumes compared to normal subjects (F=6.24, p=0.01), particularly on the fight side (F=9.76, p=0.002). Also, the laterality index for entorhinal cortex was higher in normal individuals than in patients with schizophrenia (F=5.45, p = 0.02).Conclusions: Consistent with some of the previous reports, our study confirmed the presence of abnormally decreased entorhinal volumes, particularly on the right side, in a large number of patients with schizophrenia and also found altered asymmetry. This may play a major role in the psychopathology and cognitive disturbances of the disease. Future longitudinal MRI studies including high-risk subjects and drug-free, first-episode patients are crucial to further understand whether entorhinal cortex shrinkage is already present at the onset of the illness or appears as a consequence of the illness. (c) 2007 Elsevier B.V. All rights reserved.