Development of novel linkers to conjugate pharmacophores to a carrier antibody
Development of novel linkers to conjugate pharmacophores to a carrier antibody
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DOI：
10.1016/j.bmcl.2012.05.040
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发表时间：
2012-07-01
影响因子：
2.7
通讯作者：
Bradshaw, Curt
中科院分区：
文献类型：
--
作者：
Palanki, Moorthy S. S.;Bhat, Abhijit;Bradshaw, Curt
我们已经开发出具有改进化学稳定性的改性马来酰亚胺新型连接物，可以潜在地用于将各种药物载体（如寡核苷酸、肽和蛋白质）偶联到抗体上，从而提供具有明确治疗效果和改善药代动力学特性的新型生物制剂。这些连接体扩展了药物载体与抗体生物偶联的工具阵列。(C) 2012 Elsevier Ltd.版权所有。
We have developed modified maleimide novel linkers with improved chemical stability that could potentially be used in conjugating various pharmacophores such as oligo nucleotides, peptides, and proteins to antibodies to afford novel biologics with well-defined therapeutic benefits and improved pharmacokinetic properties. These linkers expand the array of tools available for bioconjugation of pharmacophores to antibodies. (C) 2012 Elsevier Ltd. All rights reserved.