Transgenic animal models of neurodegeneration based on human genetic studies.
Transgenic animal models of neurodegeneration based on human genetic studies.
复制标题
基于人类遗传研究的神经退行性的转基因动物模型。
DOI：
10.1007/s00702-010-0476-6
复制
发表时间：
2011-01
影响因子：
3.3
通讯作者：
Airavaara, Mikko
中科院分区：
文献类型：
--
作者：
Harvey, Brandon K.;Richie, Christopher T.;Hoffer, Barry J.;Airavaara, Mikko
关键词：
阿尔茨海默病（AD）、肌萎缩性侧索硬化（ALS）、亨廷顿病（HD）和帕金森病（PD）等神经退行性疾病相关基因的鉴定导致了用于研究机制和评估潜在疗法的动物模型的发展。基于疾病相关基因开发的转基因模型都不能完全概括相应疾病的行为和病理特征。然而，在确定潜在的治疗靶点和了解神经退行性变的一些常见机制方面取得了巨大进展。在这篇综述中，我们将讨论基于人类遗传学研究的AD，ALS，HD和PD的转基因动物模型。所有讨论的疾病都有积极或完整的临床试验，用于从疾病的转基因模型中获益的实验性治疗。
The identification of genes linked to neurodegenerative diseases such as Alzheimer's disease (AD), amyotrophic lateral sclerosis (ALS), Huntington's disease (HD) and Parkinson's disease (PD) has led to the development of animal models for studying mechanism and evaluating potential therapies. None of the transgenic models developed based on disease-associated genes have been able to fully recapitulate the behavioral and pathological features of the corresponding disease. However, there has been enormous progress made in identifying potential therapeutic targets and understanding some of the common mechanisms of neurodegeneration. In this review, we will discuss transgenic animal models for AD, ALS, HD and PD that are based on human genetic studies. All of the diseases discussed have active or complete clinical trials for experimental treatments that benefited from transgenic models of the disease.
登录
查看更多内容
DOI：
10.1073/pnas.95.11.6480
发表时间：
1998-05-26
影响因子：
11.1
作者：
Cha, JHJ;Kosinski, CM;Young, AB
通讯作者：
Young, AB
影响因子：
56.9
作者：
Bonifati, V;Rizzu, P;Heutink, P
通讯作者：
Heutink, P
影响因子：
11.2
作者：
Biskup, Saskia;Moore, Darren J.;Dawson, Valina L.
通讯作者：
Dawson, Valina L.
影响因子：
5.3
作者：
Bales, Kelly R.;Liu, Feng;Paul, Steven M.
通讯作者：
Paul, Steven M.
影响因子：
3
作者：
Bennett, Steven P.;Boyd, Tim D.;Potter, Huntington
通讯作者：
Potter, Huntington