DEVELOPMENTAL MODULATIONS OF BLOOD-BRAIN-BARRIER PERMEABILITY AS AN INDICATOR OF CHANGING NUTRITIONAL-REQUIREMENTS IN THE BRAIN
DEVELOPMENTAL MODULATIONS OF BLOOD-BRAIN-BARRIER PERMEABILITY AS AN INDICATOR OF CHANGING NUTRITIONAL-REQUIREMENTS IN THE BRAIN
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DOI：
10.1203/00006450-198204000-00017
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发表时间：
1982-01-01
影响因子：
3.6
通讯作者：
OLDENDORF, WH
中科院分区：
文献类型：
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作者：
CORNFORD, EM;BRAUN, LD;OLDENDORF, WH
采用颈动脉内注射技术检测新生儿（bb0 24 h）、7、14、21、28日龄及成年家兔的血脑屏障功能。腺嘌呤、精氨酸、胆碱、乳酸和色氨酸在血脑屏障运输中的年龄相关调节被定义并证明是相互独立的。乳酸摄取异常，产后7天脑摄取指数（BUI）最大。升高的乳酸摄取持续到14天，然后降低。如下所示，对于所有其他代谢物，在新生儿大脑中观察到最大的BUI，并且BUI通常与动物年龄呈某种反比关系。精氨酸的BUI在出生后7天内明显减半，并继续下降，到21日龄时达到成年兔的水平。相反，大脑对腺嘌呤的摄取是不寻常的，因为在整个哺乳期，大脑对腺嘌呤的摄取似乎是逐渐减少的。产后2周观察到胆碱BUI下降3倍。色氨酸的摄取在出生后的头4周减少了4倍。葡萄糖和丁醇（一种参考物质，在很大的血流量范围内被大脑完全清除）的摄取在不同年龄范围内只观察到微小的变化。腺嘌呤、精氨酸、胆碱、乳酸和色氨酸通透性的调节不能归因于血流改变。
The intracarotid injection technique was used to examine blood-brain barrier function in studies of newborn (> 24 h), 7, 14, 21 and 28-day-old, as well as adult rabbits. The age-related modulations in blood-brain barrier transport of adenine, arginine, choline, lactate and tryptophan were defined and demonstrated to be independent of each other. Lactic acid uptake was unusual in that the brain uptake index (BUI) was greatest at 7 days postpartum. Elevated lactate uptake continues until 14 days and is then reduced. As indicated below, for all of the other metabolites examined, a maximal BUI was observed in the newborn brain and BUI typically showed some sort of inverse relationship to animal age. The BUI of arginine is apparently halved in the first 7 days postnatally, and continues to decrease, reaching the value seen for the adult rabbit by an age of 21 days. In contrast, the brain uptake of adenine is unusual in that there appears to be a very gradual reduction in brain uptake occurring throughout the suckling period. A 3-fold decrease in the BUI of choline was observed during the first 2 wk postpartum. Tryptophan uptake undergoes a 4-fold reduction in the first 4 wk postnatally. Only minor variations in the uptakes of glucose and butanol (a reference substance which is completely cleared by brain over a wide range of blood flow rates) were observed over the range of ages examined. Modulations in adenine, arginine, choline, lactate and tryptophan permeability are not attributable to blood flow alterations.