Fluorous Mixture Synthesis of Tripeptides and Pentapeptides using a Fluorous-Fmoc Protection Strategy

Fluorous Mixture Synthesis of Tripeptides and Pentapeptides using a Fluorous-Fmoc Protection Strategy
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使用氟-Fmoc 保护策略合成三肽和五肽的氟混合物

DOI：
10.1055/s-0036-1588698
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发表时间：
2017
期刊：
Synthesis
影响因子：
--
通讯作者：
Masato Matsugi
Masato Matsugi
中科院分区：
--
文献类型：
--
作者：
Yuya Sugiyama;Ryuhei Shirai;Masaki Hirose;Tomoko Watanabe;Ayana Yoshida;Natsuki Endo;Toshiya Hayashi;Takayuki Shioiri;Masato Matsugi

文献摘要

相似文献

采用氟-Fmoc保护策略进行了各种三肽和五肽的液相分离式合成。氟-Fmoc试剂既是氨基酸功能的保护基，又是氨基酸结构的编码标签。所制备的几个合成肽在ACE抑制试验中显示出高活性。
A liquid-phase split-type synthesis of various tripeptides and pentapeptides was conducted using a fluorous-Fmoc protection strategy. Fluorous-Fmoc reagents were effectively used as both the protecting group for the amino function and the encoding tag for the amino acid structure. Several of the synthetic peptides prepared showed high activities in an ACE inhibitory assay.