Mechanisms and experimental models of chronic obstructive pulmonary disease exacerbations.
Mechanisms and experimental models of chronic obstructive pulmonary disease exacerbations.
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DOI：
10.1513/pats.200504-025sr
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发表时间：
2005-01-01
期刊：
影响因子：
--
通讯作者：
Johnston, Sebastian L
中科院分区：
文献类型：
--
作者：
Mallia, Patrick;Johnston, Sebastian L
慢性阻塞性肺疾病（COPD）的加重是发病率、死亡率和医疗费用上升的主要原因。此外，它们与肺功能的加速丧失有关，因此对疾病进展有直接影响。很少有研究探讨COPD急性加重的细胞和分子机制。急性加重与气道炎症和氧化应激增加有关，但关于关键炎症细胞和介质的许多问题仍然没有答案。目前针对COPD急性加重的治疗效果有限，需要更好地了解急性加重时的炎症事件以设计新的治疗药物。发展急性加重的实验模型--例如，在COPD患者中使用实验性鼻病毒感染--将极大地促进急性加重的研究。
Exacerbations of chronic obstructive pulmonary disease (COPD) are a major cause of morbidity, mortality, and rising health care costs. In addition, they are associated with an accelerated loss of lung function and thus have a direct effect on disease progression. There are few studies examining the cellular and molecular mechanisms of COPD exacerbations. Exacerbations are linked to increased airway inflammation and oxidative stress, but many questions remain unanswered regarding the key inflammatory cells and mediators. Current therapies for COPD exacerbations are of limited effectiveness, and a better understanding of the inflammatory events at exacerbation is required to devise new therapeutic agents. The development of experimental models of exacerbation-for example, the use of experimental rhinovirus infection in humans with COPD-would greatly facilitate studies of exacerbations.