Nitric oxide inhibits the replication cycle of severe acute respiratory syndrome coronavirus
Nitric oxide inhibits the replication cycle of severe acute respiratory syndrome coronavirus
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DOI：
10.1128/jvi.79.3.1966-1969.2005
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发表时间：
2005-02-01
影响因子：
5.4
通讯作者：
Mirazimi, A
中科院分区：
文献类型：
--
作者：
Åkerström, S;Mousavi-Jazi, M;Mirazimi, A
一氧化氮（NO）是一种重要的细胞间信号分子，对某些病毒感染具有抑制作用。本研究的目的是研究NO是否抑制严重急性呼吸综合征冠状病毒（SARS CoV）在体外的复制周期。我们发现，有机NO供体，S-亚硝基-N-乙酰青霉胺，显着抑制SARS冠状病毒的复制周期中的浓度依赖性的方式。我们还表明，NO抑制病毒蛋白质和RNA的合成。此外，我们表明，诱导型一氧化氮合酶，一种酶，产生NO，抑制SARS冠状病毒复制周期。
Nitric oxide (NO) is an important signaling molecule between cells which has been shown to have an inhibitory effect on some virus infections. The purpose of this study was to examine whether NO inhibits the replication cycle of the severe acute respiratory syndrome coronavirus (SARS CoV) in vitro. We found that an organic NO donor, S-nitroso-N-acetylpenicillamine, significantly inhibited the replication cycle of SARS CoV in a concentration-dependent manner. We also show here that NO inhibits viral protein and RNA synthesis. Furthermore, we demonstrate that NO generated by inducible nitric oxide synthase, an enzyme that produces NO, inhibits the SARS CoV replication cycle.