Eruptive Pseudoangiomatosis: Report of an Adult Case and Unifying Hypothesis of the Pathogenesis of Paediatric and Adult Cases
Eruptive Pseudoangiomatosis: Report of an Adult Case and Unifying Hypothesis of the Pathogenesis of Paediatric and Adult Cases
复制标题
爆发性假性血管瘤病：一例成人病例的报告以及儿童和成人病例发病机制的统一假设
DOI：
10.1159/000102035
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发表时间：
2007
期刊：
影响因子：
3.4
通讯作者：
I. Bassukas
中科院分区：
文献类型：
--
作者：
Ioannis Chaniotakis;K. Nomikos;C. Gamvroulia;A. Zioga;C. Stergiopoulou;I. Bassukas
一名50岁女性患者在接受糖皮质激素和吗替麦考酚酯免疫抑制治疗后1个月发生了新的皮疹，临床和组织形态学与发疹性假血管瘤病（EP）一致。其自限性病程进一步证实了这一诊断。虽然最初描述为儿科皮疹，但同时文献中报告了更多的EP成人病例（Medline检索确定的53例病例中有30例）。对EP成人病例的审查揭示了一些共同的临床和流行病学特征：成人EP病例往往聚集在欧洲地中海地区，在夏季发展，有时以有限的微流行病形式出现，影响免疫功能低下的个体，病变局限于暴露的皮肤部位。这些特点，加上儿童疾病的exanthematic性质，指出一些病媒传播的传染性病原体是这种可能诊断不足的疾病的原因。
One month after the onset of immunosuppressive treatment with corticosteroids and mycophenolate mofetil for a newly diagnosed pemphigus vulgaris, a 50-year-old female patient developed a new eruption clinically and histomorphologically consistent with eruptive pseudoangiomatosis (EP). Its self-limited course further confirmed this diagnosis. Although initially described as a paediatric eruption, meanwhile more adult cases of EP (30 out of a total of 53 cases identified by a Medline search) are reported in the literature. The review of adult cases of EP disclosed some common clinical and epidemiological characteristics: adult EP cases tend to cluster in the Mediterranean region of Europe, develop during the summer months, sometimes in the form of limited micro-epidemics, affect immunocompromised individuals and have lesions confined to the exposed skin sites. These characteristics, together with the exanthematic nature of the disease in children, point to some vector-transmitted infectious agent as the cause of this probably underdiagnosed disease.