Bone regeneration in defects compromised by radiotherapy.
Bone regeneration in defects compromised by radiotherapy.
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DOI：
10.1177/0022034509352151
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发表时间：
2010-01
影响因子：
7.6
通讯作者：
Krebsbach PH
中科院分区：
文献类型：
--
作者：
Hu WW;Ward BB;Wang Z;Krebsbach PH
Critical-sized defects were created in rat calvariae previously treated with 12 Gy irradiation 2 weeks before surgery. Gelatin scaffolds containing lyophilized AdBMP-2, freely suspended AdBMP-2, or negative controls were transplanted in the defects for 5 weeks. Lyophilized AdBMP-2 treatment significantly improved both bone quality and quantity over free AdBMP-2 administration. The effects of radiotherapy on osteogenesis were also compared. Bone mineral density was reduced after radiotherapy. Histological analyses demonstrated that radiation damage led to less bone regeneration. Woven bone and immature marrow formed in the radiated defects indicated that preoperative radiotherapy retarded normal bone development and turnover. Finally, the gelatin scaffolds with lyophilized AdBMP-2 were stored at -80°C to determine adenovirus stability. Micro-CT quantification demonstrated that there were no significant differences between bone regeneration treated with lyophilized AdBMP-2 before and after 1-month storage, suggesting that virus-loaded scaffolds should be convenient for application as pre-made constructs for surgical applications.
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影响因子：
3.5
作者：
Hu, Wei-Wen;Lang, Michael W.;Krebsbach, Paul H.
通讯作者：
Krebsbach, Paul H.
DOI：
10.1016/s0360-3016(00)00447-8
发表时间：
2000-06-01
影响因子：
7
作者：
Fields, MT;Eisbruch, A;Lawrence, TS
通讯作者：
Lawrence, TS
影响因子：
6.2
作者：
Yang, SY;Wei, DY;Franceschi, RT
通讯作者：
Franceschi, RT
影响因子：
6.2
作者：
Kaigler, D;Wang, Z;Krebsbach, PH
通讯作者：
Krebsbach, PH
影响因子：
4.2
作者：
Nussenbaum, B;Rutherford, RB;Krebsbach, PH
通讯作者：
Krebsbach, PH