Styrene metabolism, genotoxicity, and potential carcinogenicity
Styrene metabolism, genotoxicity, and potential carcinogenicity
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DOI：
10.1080/03602530600952222
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发表时间：
2006-01-01
影响因子：
5.9
通讯作者：
Oesch, Franz
中科院分区：
文献类型：
--
作者：
Vodicka, Pavel;Koskinen, Mikko;Oesch, Franz
本报告回顾了苯乙烯的生物转化，包括次要代谢途径，并将代谢与遗传毒性效应和可能的苯乙烯相关致癌性联系起来。研究表明，苯乙烯需要代谢活化才能产生显著的遗传毒性，苯乙烯7，8-氧化物对苯乙烯的遗传毒性的贡献最大（在人体中大于95%），而小环氧化产物也会导致局部毒性，尤其是在呼吸系统中。根据代谢多态性和个体DNA修复能力的个体易感性，以及在所讨论的物种中的剂量-反应关系的非线性的依赖性和风险评估的后果进行了分析。
This report reviews styrene biotransformation, including minor metabolic routes, and relates metabolism to the genotoxic effects and possible styrene-related carcinogenicity. Styrene is shown to require metabolic activation in order to become notably genotoxic and styrene 7,8-oxide is shown to contribute quantitatively by far the most (in humans more titan 95%) to the genotoxicity of styrene, while minor ring oxidation products are also shown to contribute to local toxicities, especially in the respiratory system. Individual susceptibility depending on metabolism polymorphisms and individual DNA repair capacity as well as the dependence of the nonlinearity of the dose-response relationships in the species in question and the consequences for risk evaluation are analyzd.