Cytokine expression profile in idiopathic inflammatory myopathies
Cytokine expression profile in idiopathic inflammatory myopathies
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DOI：
10.1097/00005072-199603000-00009
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发表时间：
1996-03-01
影响因子：
3.2
通讯作者：
Goebel, HH
中科院分区：
文献类型：
--
作者：
Tews, DS;Goebel, HH
细胞因子已被证明是有效的诱导剂的主要组织相容性复合物（MHC）类I和II，以及细胞粘附分子在肌肉组织培养，表明细胞因子可能发挥作用，在介导肌纤维损伤的炎性肌病。我们在21例自身免疫性肌炎中发现了不同数量的表达白细胞介素（IL）-1 α和β，IL-2，IL-4，肿瘤坏死因子（TNF）-α和β，干扰素（IFN）-γ及其受体的炎性细胞。肌纤维显示IL-1 α和β、IL-2和TNF-α的表达增强。细胞因子的上调在相应肌炎亚型典型的细胞浸润部位最强。细胞因子表达与炎症分级无相关性。在较小程度上，细胞因子也存在于Duchenne肌营养不良症中，由TNF-α阳性的肌纤维和吞噬单核细胞表达。通过肌纤维表达细胞因子可以使肌纤维能够诱导和介导自身免疫和抗原表达的过程，而无需炎性细胞的主要存在。表达细胞因子的肌纤维可以增强细胞毒性细胞的细胞溶解潜力，并且肌纤维可以充当源和靶。
Cytokines have been shown to be potent inducers of major histocompatibility complexes (MHC) class I and II as well as of cell adhesion molecules in muscle tissue cultures, indicating that cytokines may play a role in mediating muscle fiber damage in inflammatory myopathies. We found in 21 cases of autoimmune myositis various amounts of inflammatory cells expressing interleukin (IL)-1 alpha and -beta, IL-2, IL-4, tumor necrosis factor (TNF)-alpha and -beta, and interferon (IFN)-gamma and its receptor. Muscle fibers displayed enhanced expression of IL-1 alpha and -beta, IL-2, and TNF-alpha. Upregulation of cytokines was strongest at sites of cellular infiltration typical for the respective myositis subtype. There was no correlation between the cytokine expression and the grade of inflammation. To a lesser extent, cytokines were also present in Duchenne muscular dystrophy expressed by muscle fibers positive for TNF-alpha and by phagocytic mononuclear cells. Expression of cytokines by the muscle fiber may enable the muscle fiber to induce and mediate the process of autoimmunization and antigen-expression by itself without primary presence of inflammatory cells. Cytokine-expressing muscle fibers may enhance the cytolytic potential of cytotoxic cells and the muscle fiber may serve as source and target.