Chemo-physical Strategies to Advance the in Vivo Functionality of Targeted Nanomedicine: The Next Generation
Chemo-physical Strategies to Advance the in Vivo Functionality of Targeted Nanomedicine: The Next Generation
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DOI：
10.1021/jacs.0c09029
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发表时间：
2021-01-20
影响因子：
15
通讯作者：
Kataoka, Kazunori
中科院分区：
文献类型：
--
作者：
Li, Junjie;Kataoka, Kazunori
过去几十年见证了纳米医学从生物惰性实体向更智能系统的演变，旨在提高体内功能。然而，我们应该认识到，大多数系统仍然依赖于合理的解释——包括一些过度解释——而不是明确的证据，这是一个分水岭，从根本上决定了纳米医学进步的速度和程度。在组织、细胞和分子水平上探索纳米生物相互作用和所需的功能最常被忽视。回答这些问题的进展将为指导更有效的化学物理策略提供指导性见解。因此，在下一代，我们认为应该付出很大的努力来为机制验证提供明确的证据，而不是为类似的概念验证创建许多新的、复杂的系统。
The past few decades have witnessed an evolution of nanomedicine from biologically inert entities to more smart systems, aimed at advancing in vivo functionality. However, we should recognize that most systems still rely on reasonable explanation-including some over-explanation-rather than definitive evidence, which is a watershed radically determining the speed and extent of advancing nanomedicine. Probing nano-bio interactions and desirable functionality at the tissue, cellular, and molecular levels is most frequently overlooked. Progress toward answering these questions will provide instructive insight guiding more effective chemo-physical strategies. Thus, in the next generation, we argue that much effort should be made to provide definitive evidence for proof-of-mechanism, in lieu of creating many new and complicated systems for similar proof-of-concept.