AQP5 promotes hepatocellular carcinoma metastasis via NF-κB-regulated epithelial-mesenchymal transition
AQP5 promotes hepatocellular carcinoma metastasis via NF-κB-regulated epithelial-mesenchymal transition
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DOI：
10.1016/j.bbrc.2017.06.046
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发表时间：
2017-08-19
影响因子：
3.1
通讯作者：
Ren, Xuequn
中科院分区：
文献类型：
--
作者：
He, Zhikuan;Dong, Wenxing;Ren, Xuequn
水通道蛋白5（Aquaporin 5，AQP 5）是一种跨膜蛋白，与慢性肾脏病、全身性疾病等多种疾病的发生、发展密切相关。最近，AQP 5已被报道在癌症进展中发挥重要作用。然而，关于其在肝细胞癌（HCC）中的确切功能知之甚少。本研究旨在探讨AQP 5在肝癌中的作用。结果表明，AQP 5在肝癌细胞系中高表达，其下调可抑制肝癌细胞的侵袭和肿瘤转移。此外，AQP 5的下调通过调节EMT相关分子如E-cadherin、α-catenin、N-cadherin和Vimentin来抑制HCC细胞中的上皮-间质转化（EMT）过程。相关机制的进一步研究表明，AQP 5下调可能通过抑制NF-κ B B信号通路而抑制HCC的转移和EMT。总之，这些发现表明AQP 5可能是HCC的潜在治疗靶点。(C)2017爱思唯尔公司All rights reserved.
Aquaporin 5 (AQP5), a transmembrane protein, is known for its involvement in the progress of many diseases such as chronic kidney disease and systemic disease. Recently, AQP5 has been reported to play an important role in cancer progression. However, little is known about its precise functions in hepatocellular carcinoma (HCC). This study aimed to investigate the specific role of AQP5 in HCC. The results showed that AQP5 was highly expressed in HCC cell lines and its down-regulation inhibited HCC cell invasion and tumor metastasis in vitro and in vivo. In addition, down-regulation of AQP5 suppressed the epithelial-mesenchymal transition (EMT) process in HCC cells by modulating EMT-related molecules such as E-cadherin, alpha-catenin, N-cadherin and Vimentin. Further studies on corresponding mechanisms indicated that AQP5 down-regulation inhibited HCC metastasis and EMT partly via inactivation of the NF-kappa B signaling pathway. Taken together, these findings suggest that AQP5 may be a potential therapeutic target for HCC. (C) 2017 Elsevier Inc. All rights reserved.