Mitochondrial biology in reproduction.
Mitochondrial biology in reproduction.
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DOI：
10.1007/s12522-011-0101-x
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发表时间：
2011-12-01
影响因子：
3.4
通讯作者：
Pinkert, Carl A
中科院分区：
文献类型：
--
作者：
Cannon, Matthew V;Takeda, Kumiko;Pinkert, Carl A
线粒体生物学在生殖过程中起着重要作用，影响生殖细胞的发育和质量，影响胚胎发育和生殖成功。本文综述了线粒体遗传学和功能在生殖生物学中的作用，包括线粒体一般功能、遗传学和种系传播的讨论。还强调了在卵子发生过程中发生的线粒体形态变化，以及这些变化在影响有害线粒体基因组向后代分布的线粒体瓶颈中所起的作用。本文综述了线粒体在胚胎干细胞和诱导多能干细胞生物学和发育中的作用。最后，讨论了线粒体生物学在辅助生殖技术中的作用。
Mitochondrial biology plays an important role in the reproductive process, with influence on germ cell development and quality as well as embryonic development and reproductive success. This review outlines the role of mitochondrial genetics and function in reproductive biology, including a discussion of general mitochondrial function, genetics and germline transmission. Also highlighted are the mitochondrial morphologic changes that occur during oogenesis and the role these changes play in the mitochondrial bottleneck that influences the distribution of deleterious mitochondrial genomes to offspring. The review covers the influence of mitochondria in embryonic stem cell and induced pluripotent stem cell biology and development. Lastly, the role of mitochondrial biology in assisted reproductive techniques is discussed.