Psychometric Properties of the NIH Toolbox Cognition Battery in Healthy Older Adults: Reliability, Validity, and Agreement with Standard Neuropsychological Tests
Psychometric Properties of the NIH Toolbox Cognition Battery in Healthy Older Adults: Reliability, Validity, and Agreement with Standard Neuropsychological Tests
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DOI：
10.1017/s1355617719000614
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发表时间：
2019-09-01
影响因子：
2.6
通讯作者：
Benitez, Andreana
中科院分区：
文献类型：
--
作者：
Scott, Emmi P.;Sorrell, Anne;Benitez, Andreana
目的：很少有独立的研究检查了老年人的NIH认知成套测验（NIHTB-CB）的心理测量学特性，尽管人们对其用于临床目的的兴趣越来越大。在本文中，我们报告的重测信度和结构效度的NIHTB-CB，以及它的协议或一致性与传统的神经心理测试相同的结构，以确定是否可以互换使用的测试。方法：61名年龄在60-80岁的认知健康成年人完成了“金标准”（GS）神经心理学测试、NIHTB-CB和脑MRI。重测信度，收敛/判别效度和协议统计使用皮尔逊相关系数，一致性相关系数（CCC），和均方根偏差计算。结果：重测信度是可接受的（CCC = .73液体; CCC = .85结晶）。NIHTB-CB流体复合物与脑容量显著相关（r = 0.9999）。|.35-.41|），两种复合材料与其各自的GS复合材料高度相关（r = 0.58 - 0.84），尽管这对于单独的测试来说是更可变的。由于NIHTB-CB上液体评分的精密度较低和结晶复合评分的系统性高估，绝对一致性通常较低（CCC = .55液体; CCC = .70结晶）。结论：这些结果支持NIHTB-CB在健康老年人中的可靠性和有效性，并表明流体复合测试至少与标准神经心理学测试一样敏感，以内侧颞叶萎缩和心室扩张。然而，NIHTB-CB可能会产生不同的性能估计，不应该被视为可互换的既定的神经心理测试。
Objective: Few independent studies have examined the psychometric properties of the NIH Toolbox Cognition Battery (NIHTB-CB) in older adults, despite growing interest in its use for clinical purposes. In this paper we report the test-retest reliability and construct validity of the NIHTB-CB, as well as its agreement or concordance with traditional neuropsychological tests of the same construct to determine whether tests could be used interchangeably. Methods: Sixty-one cognitively healthy adults ages 60-80 completed "gold standard" (GS) neuropsychological tests, NIHTB-CB, and brain MRI. Test-retest reliability, convergent/discriminant validity, and agreement statistics were calculated using Pearson's correlations, concordance correlation coefficients (CCC), and root mean square deviations. Results: Test-retest reliability was acceptable (CCC = .73 Fluid; CCC = .85 Crystallized). The NIHTB-CB Fluid Composite correlated significantly with cerebral volumes (r's = |.35-.41|), and both composites correlated highly with their respective GS composites (r's = .58-.84), although this was more variable for individual tests. Absolute agreement was generally lower (CCC = .55 Fluid; CCC = .70 Crystallized) due to lower precision in fluid scores and systematic overestimation of crystallized composite scores on the NIHTB-CB. Conclusions: These results support the reliability and validity of the NIHTB-CB in healthy older adults and suggest that the fluid composite tests are at least as sensitive as standard neuropsychological tests to medial temporal atrophy and ventricular expansion. However, the NIHTB-CB may generate different estimates of performance and should not be treated as interchangeable with established neuropsychological tests.