The acute effect of flavonoid-rich apples and nitrate-rich spinach on cognitive performance and mood in healthy men and women
The acute effect of flavonoid-rich apples and nitrate-rich spinach on cognitive performance and mood in healthy men and women
复制标题
DOI：
10.1039/c3fo60590f
复制
发表时间：
2014-05-01
期刊：
影响因子：
6.1
通讯作者：
Hodgson, Jonathan M.
中科院分区：
文献类型：
--
作者：
Bondonno, Catherine P.;Downey, Luke A.;Hodgson, Jonathan M.
水果和蔬菜饮食中的黄酮和硝酸盐可能通过影响一氧化氮（NO）状态来预防心血管疾病和认知能力下降。循环NO池通过不同的途径增加膳食黄酮和硝酸盐。我们的目的是调查苹果，富含黄酮类化合物，菠菜，富含硝酸盐，独立和组合对NO状态，认知功能和情绪的急性影响，在一项随机，对照，交叉试验中，健康男性和女性（n = 30）。比较了四种能量匹配处理（对照、苹果、菠菜和苹果+菠菜）的急性效应。终点包括血浆一氧化氮状态（通过测量S-亚硝基硫醇+其他亚硝基物质（RXNO）确定）、血浆硝酸盐和亚硝酸盐、唾液硝酸盐和亚硝酸盐、尿硝酸盐和亚硝酸盐以及认知功能（使用认知药物研究（CDR）计算机认知评估组合确定）和情绪。相对于对照，所有处理导致更高的血浆RXNO。与对照组相比，菠菜和苹果+菠菜组的血浆硝酸盐和亚硝酸盐、唾液硝酸盐和亚硝酸盐以及尿硝酸盐和亚硝酸盐显著增加。对认知功能或情绪没有显著影响。总之，富含类黄酮的苹果和富含硝酸盐的菠菜急性增强了NO状态，但没有伴随认知功能和情绪的改善或恶化。
Flavonoids and nitrate in a fruit and vegetable diet may be protective against cardiovascular disease and cognitive decline through effects on nitric oxide (NO) status. The circulating NO pool is increased via distinct pathways by dietary flavonoids and nitrate. Our aim was to investigate the acute effects of apples, rich in flavonoids, and spinach, rich in nitrate, independently and in combination on NO status, cognitive function and mood in a randomised, controlled, cross-over trial with healthy men and women (n = 30). The acute effects of four energy-matched treatments (control, apple, spinach and apple + spinach) were compared. Endpoints included plasma nitric oxide status (determined by measuring S-nitrosothiols + other nitroso species (RXNO)), plasma nitrate and nitrite, salivary nitrate and nitrite, urinary nitrate and nitrite as well as cognitive function (determined using the Cognitive Drug Research (CDR) computerized cognitive assessment battery) and mood. Relative to control, all treatments resulted in higher plasma RXNO. A significant increase in plasma nitrate and nitrite, salivary nitrate and nitrite as well as urinary nitrate and nitrite was observed with spinach and apple + spinach compared to control. No significant effect was observed on cognitive function or mood. In conclusion, flavonoid-rich apples and nitrate-rich spinach augmented NO status acutely with no concomitant improvements or deterioration in cognitive function and mood.